pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Intensification of steel melting process in blast furnace by means of bottom blowing by inert gas
Литьë и металлургия, 2002 With application of physical and mathematical modeling there is carried out complex estimation of efficiency of different kinds of inert-gas flushing of ark steel furnace.
P. P. Bizjukov +5 more
doaj
The Contribution of Mechanical Spectroscopy to Understanding Grain Boundary Sliding [PDF]
Materials Research, 2018 This review paper shows that grain boundary sliding (GBS) is a general phenomenon occurring in all classes of inorganic materials: ceramics, metals and composite materials.
Daniele Mari
doaj +1 more source
Reliable irogane alloys and niiro patination—further study of production and application to jewelry [PDF]
, 2010 Japanese metalworkers use a wide range of irogane alloys (shakudo, shibuichi), which are colored with a single patination solution (niiro eki). This approach allows different alloys to be combined in one piece and patinated, producing a multi-colored ...
Jones, Alan Hywel, O'Dubhghaill, Coilin
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Reducing the tension-compression yield asymmetry in an extruded ZK60 alloy by ultrafine grains
Materials Research Express, 2018 Ultrafine-grained ZK60 alloys were successfully fabricated by powder metallurgy followed by hot extrusion at different temperatures. The effects of the texture changes of ultrafine-grained ZK60 magnesium alloy on the asymmetry of tension-compression ...
Jinhui Wang +5 more
doaj +1 more source
APPLICATION OF POLYSTYRENE FOAM CORE FUSIBLE PATTERNS IN PRODUCTION OF GAS TURBINES’ CAST PARTS
Литьë и металлургия, 2016 The task of replacing the LVM dissolves polystyrene molding on models is at the present time, technologically, economically and environmentally promising from the point of view of industrial applications for gas turbine plants in Ukraine.
O. I. Shinsky +4 more
doaj +1 more source
Ti–Pd Alloys as Heterogeneous Catalysts for Hydrogen Autotransfer Reaction and Catalytic Improvement by Hydrogenation Effects [PDF]
, 2019 Ti−Pd alloys were investigated as heterogeneous catalysts for hydrogen autotransfer reactions. This is the first reported study of alloys as catalysts for hydrogen‐borrowing reactions using alcohols.
Kondo Ryota +8 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source