Results 51 to 60 of about 1,128,663 (304)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Almost periodic functions in quantum calculus

Electronic Journal of Differential Equations, 2018
In this article, we introduce the concepts of Bochner and Bohr almost periodic functions in quantum calculus and show that both concepts are equivalent.
Martin Bohner, Jaqueline G. Mesquita
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Periodicity and almost periodicity for solutions of third-order differential equations with piecewise constant argument

四川大学学报. 自然科学版, 2020
In this paper, we consider the third-order differential equation with piecewise constant argument. We first give the form of the solution in term of the solution of the corresponding difference equation.
ZHANG Bao, LI Hong-Xu
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Almost periodicity of solutions for almost periodic evolution equations

Differential and Integral Equations, 2005
In this paper, we discuss almost periodicity of solutions for evolution equations in Banach space. We introduce the concept of difference-variation equation. For a special Hilbert space, we establish some results on almost periodicity of all solutions for evolution equations. In particular, we extend Haraux's result on $R^2$ to $R^n.$
Hu, Zuosheng, Mingarelli, Angelo B.
openaire   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Connectedness related to almost periodicity of compositions of flow homomorphisms [PDF]

, 1987
Consider homomorphisms ϕ : X → Y and ψ : Y → Z, where ϕ is open and N-to-one, ψ is almost periodic. In the paper by R. J Sacker and G. R. Sell, it was shown that, under a certain condition on the phase group, the composition ψ ∘ϕ : X → Z is almost ...
Woude, van der, J.C.S.P., Jaap van der Woude, Ta-Sun Wu, Douglas McMahon, McMahon, D.C., Wu, T.S.   +5 more
core   +1 more source

Almost periodic distributions and crystalline measures

Математичні Студії
We study temperate distributions and measures with discrete support in Euclidean space and their Fourier transforms with special attention to almost periodic distributions.
S. Yu. Favorov
doaj   +1 more source