Results 51 to 60 of about 24,571 (250)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Contact metric manifolds with large automorphism group and (κ, µ)-spaces
Complex Manifolds, 2019 We discuss the classifiation of simply connected, complete (κ, µ)-spaces from the point of view of homogeneous spaces. In particular, we exhibit new models of (κ, µ)-spaces having Boeckx invariant -1.
Lotta Antonio
doaj +1 more source
, 2020 For almost contact metric or almost paracontact metric manifolds there is natural notion of $η$-normality. Manifold is called $η$-normal if is normal along kernel distribution of characteristic form. In the paper it is proved that $η$-normal manifolds are in one-one correspondence with Cauchy-Riemann almost contact metric manifolds or para Cauchy ...
openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
MathematicsAlmost contact complex Riemannian manifolds, also known as almost contact B-metric manifolds, are equipped with Ricci–Bourguignon-like almost solitons.
Mancho Manev
doaj +1 more source
Дифференциальная геометрия многообразий фигур, 2022 Six-dimensional planar submanifolds of Cayley algebra equipped with almost Hermitian structures induced by Brown — Gray three-fold vector cross products in are considered.
G.A. Banaru
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Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Statistical cosymplectic manifolds and their submanifolds
پژوهشهای ریاضی, 2022 Introduction Let p(x,ζ) be the set of parametric probability distribution with parameter ζ=ζ1,…,ζn∊Rn. This set is called a statistical model or manifold. The distance between two points is measured by the Fisher metric. In general, statistical manifolds
Mohammad Bagher Kazemi, Shiva Salahvarzi
doaj
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source