Results 71 to 80 of about 374,684 (258)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Almost complex and almost contact structures in fibred Riemannian spaces

Hiroshima Mathematical Journal, 1988
Relations among structures of fibre spaces [cf. e.g. \textit{S. Ishihara} and \textit{M. Konishi}, Differential geometry of fibred spaces (Tokyo 1973; Zbl 0337.53001)] with almost Hermitian or almost contact metric structures and those of base spaces and fibres are studied.
Tashiro, Yoshihiro, Kim, Byung Hak
openaire   +2 more sources

On some almost contact metric hypersurfaces of W4-manifolds

Дифференциальная геометрия многообразий фигур, 2018
It is proved that 3-hypersurfaces of W4-manifolds admit an almost contact metric structures that can be identical to the structure induced on 2-hypersurfaces of such manifolds.
M. Banaru
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Structures on the Product of Two Almost Hermitian Almost Contact Manifolds

International Electronic Journal of Geometry, 2016
The purpose of this paper is to define some classes of almost contact metric 3-structures manifoldsand almost quaternionic metric with an almost Hermitian almost contact metric structure. Next,we construct an almost quaternionic Hermitian structure on the product of two almost Hermitianalmost contact metric structures.
BELDJİLALİ, Gherici, BELKHELFA, Mohamed   +1 more
openaire   +3 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

On the almost contact metric structure of cosymplectic type on a hypersurface of a Kähler manifold

Дифференциальная геометрия многообразий фигур, 2018
It is proved that the matrix of the second fundamental form of the immersion of a hypersurfaces of a Kähler manifold, equipped with an almost contact metric structure of cosymplectic type, is of special kind.
G. Banaru
doaj