Results 81 to 90 of about 6,310,275 (287)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Approximation of almost periodic functions by periodic ones [PDF]

open access: yes, 1998
summary:It is not the purpose of this paper to construct approximations but to establish a class of almost periodic functions which can be approximated, with an arbitrarily prescribed accuracy, by continuous periodic functions uniformly on ${\mathbb R} =
Fischer, Alexander
core  

On Fuzzy P-Continuous Functions [PDF]

open access: yes, 2007
In this paper, by using fuzzy property P, characterizations and properties of some types of fuzzy continuous functions including fuzzy continuous, fuzzy almost continuous, fuzzy c-continuous, fuzzy almost c-continuous, fuzzy c*-continuous, fuzzy s ...
Ekici, Erdal
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Almost ps-continuous functions

open access: yesTamkang Journal of Mathematics, 2012
The purpose of this paper is to introduce a new class of functions called almost ps-continuous function by using ps-open sets in topological spaces. Some properties and characterizations of this function are given.
Alias Barakat Khalaf, Baravan A. Asaad
openaire   +2 more sources

A framework including the theories of continuous functions and certain non-continuous functions

open access: yes, 1990
A framework unifying the theories of continuous functions and certain non-continuous functions including weakly continuous function,almost continuous functions,c-continuous functions, $c*$-continuous functions,$\ell$-continuous functions, s-continuous ...
Kohli, J.K.
core   +1 more source

Fuzzy δ∗-almost continuous and fuzzy δ∗-continuous functions in mixed fuzzy ideal topological spaces

open access: yes, 2020
In this paper we introduce two new classes of functions between mixed fuzzy topological spaces, namely fuzzy δ∗-almost continuous and fuzzy δ∗-continuous functions and investigate some of their properties.
Tripathy, Binod Chandra   +1 more
core   +1 more source

Bounded and almost automorphic solutions of a Liénard equation with a singular nonlinearity

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2008
We study some properties of bounded and $C^{(1)}$-almost automorphic solutions of the following Li\'enard equation: $$x'' + f(x)x' + g(x) = p(t), $$ where $p : {\bf R} \longrightarrow {\bf R}$ is an almost automorphic function, $f$, $g : (a,b ...
P. Cieutat   +2 more
doaj   +1 more source

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