Results 71 to 80 of about 448,963 (253)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Examples of almost Einstein structures on products and in cohomogeneity one

open access: yesDifferential Geometry and its Applications, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Precise additive fabrication of wall structure on thin plate end with interlayer temperature monitoring

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
Turbine blades need to be repaired to extend their product life, because they are used in highly heated centrifugal fields and often suffer damage such as cracks, chippings, and oxidation thinning.
Takenao TSURUMAKI   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Riemannian almost product manifolds generated by a circulant structure

open access: yes, 2017
A 4-dimensional Riemannian manifold equipped with a circulant structure, which is an isometry with respect to the metric and its fourth power is the identity, is considered. The almost product manifold associated with the considered manifold is studied.
Gribacheva, Dobrinka, Razpopov, Dimitar
openaire   +2 more sources

“Jamaican Sound Keroncong”: A Communication Study on the Spread of Keroncong in the Young Generation in Bandung

open access: yesHumaniora, 2019
This research discussed Jamaican Sound Keroncong (JSK) as a communication media in the global era. The problem of research was that keroncong music tended to be unknown by most young people in Bandung, and it was lost almost a century among them.
Hery Supiarza, Cece Sobarna
doaj   +3 more sources

Geometric Inequalities for Skew CR-Warped Product Submanifolds in Locally Conformal Almost Cosymplectic Manifolds

open access: yesMathematics
In this paper, we investigate contact skew CR-warped product submanifolds of locally conformal almost cosymplectic manifolds, a framework that simultaneously generalizes warped product pseudo-slant, semi-slant, and contact CR-submanifolds.
Ali H. Alkhaldi   +3 more
doaj   +1 more source

cis-(Pyridin-2-ylcarbonimidodithioato-κ2S,S′)bis(triphenylphosphane-κP)palladium(II)

open access: yesActa Crystallographica Section E, 2011
The title compound, [Pd(C6H4N2S2)(C18H15P)2], was obtained as a minor product from the reaction of trans-PdCl2(PPh3)2 with piperazine-1,4-dicarbothioic acid bis(pyridin-2-yl)amide. The PdII atom displays a slightly distorted square-planar PdP2S2 geometry
Vasily I. Pekhnyo   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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