Results 41 to 50 of about 2,348,291 (294)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

On almost sure convergence rates for the kernel estimator of a covariance operator under negative association [PDF]

Journal of Mahani Mathematical Research
It is suppose that $\{X_n,~n\geq 1\}$ is a strictly stationary sequence of negatively associated random variables with continuous distribution function F.
Hadi Jabbari
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cooling down stochastic differential equations: almost sure convergence [PDF]

, 2022
We consider almost sure convergence of the SDE $dX_t=\alpha_t d t + \beta_t d W_t$ under the existence of a $C^2$-Lyapunov function $F:\mathbb R^d \to \mathbb R$. More explicitly, we show that on the event that the process stays local we have almost sure
Kassing, S., Dereich, S., Sebastian Kassing, Steffen Dereich   +3 more
core   +1 more source

On H -Valued Continuous Robbins - Monro Processes. [PDF]

The Egyptian Statistical Journal, 1998
In this work, we consider a continuous Robbins - Monro process in a Hilbert space, a nonlinear mapping ƒ is treated instead of the usual linearity assumption.
Hoda Ali, Hala Elnagar
doaj   +1 more source

Convergence in probability and almost sure with applications

Stochastic Processes and their Applications, 2001
The paper investigates convergence in probability of an adapted real-valued stochastic process when the time is tending to infinity. Provided convergence in law, the author presents conditions equivalent to the convergence in probability. Moreover, an almost surely convergent process is constructed in that case.
openaire   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Almost sure convergence of a semidiscrete Milstein scheme for SPDE's of Zakai type [PDF]

, 2009
A semidiscrete Milstein scheme for stochastic partial differential equations of Zakai type on a bounded domain of R^d is derived. It is shown that the order of convergence of this scheme is 1 for convergence in mean square sense.
Potthoff, Jürgen, Lang, Annika, Lang, Annika,, Jürgen Potthoff, Pao-Liu Chow, Chow, P. -L., Potthoff, J., Annika Lang, Chow, Pao-Liu   +8 more
core   +2 more sources