ALOX5 regulates vascular smooth muscle cells pyroptosis to affect abdominal aortic aneurysm formation [PDF]
Scientific ReportsALOX5 is a member of the lipoxygenase (LOX) family. It is ubiquitous in all tissues and cells of the human body and participates in cell metabolism, and is closely related to human inflammation and occurrence and development of various diseases.
Luobo Wang, Bing Wang
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Cancer Medicine, 2021 Background Recent studies highlight the regulatory role of arachidonate lipoxygenase5 (Alox5) and its metabolite 5‐hydroxyeicosatetraenoic acid (5‐HETE) in cancer tumorigenesis and progression.
Peng Duan, Jian Long
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Targeting ALOX5 ameliorates renal tubular injury in ischemia–reperfusion-induced acute kidney injury via inhibition of ferroptosis [PDF]
Communications BiologyIschemia-reperfusion injury (IRI)-induced acute kidney injury (AKI) could be potentially lethal in clinic. We found lipoxygenases-5 (ALOX5) was upregulated in renal tubular cells in IRI-induced AKI; however, its underlying mechanism is not clear. In this
Liming Huang +13 more
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Celastrol suppresses bone destruction in rheumatoid arthritis by inhibiting ALOX5 expression in macrophages via the NF-κB pathway [PDF]
Scientific ReportsRheumatoid arthritis (RA) is a complex and highly disabling chronic autoimmune disease. As the disease progresses, patients often develop complications such as joint destruction and cardiovascular diseases, posing significant threats to human health ...
YiQing Chen +7 more
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YTHDF1-regulated ALOX5 in retinal pigment epithelial cells under hypoxia enhances VEGF expression and promotes viability, migration, and angiogenesis of vascular endothelial cells [PDF]
Scientific ReportsUpregulation of vascular endothelial growth factor (VEGF) and enhanced angiogenesis have been implicated in the severe progression of age-related macular degeneration (AMD). Abnormal arachidonate 5-lipoxygenase (ALOX5) is associated with AMD pathogenesis.
Panshi Yan
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Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice [PDF]
Metabolites, 2021 Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating ...
Eugenia Marbach-Breitrück +13 more
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Efficacy and Mechanism Evaluation, 2015 Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro +13 more
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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape [PDF]
Cell Death and Disease, 2023 Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especially for patients with traditional therapy ...
Tianyao Liu +21 more
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ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia [PDF]
Scientific Reports, 2017 MLL-rearranged acute myeloid leukemia (AML) remains a fatal disease with a high rate of relapse and therapeutic failure due to chemotherapy resistance. In analysis of our Affymetrix microarray profiling and chromatin immunoprecipitation (ChIP) assays, we
Yungui Wang +13 more
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Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling
Cells, 2022 Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
, Jin Wang
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