Results 91 to 100 of about 12,524 (227)

Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction

Frontiers in Cardiovascular Medicine
BackgroundThe mortality of patients with acute myocardial infarction (MI) raised rapidly in last decade and obesity are becoming the major cause to CAD progression, thus inducing heart failure preserved ejection fraction (HFpEF).
Ruiying Zhang, Ruiying Zhang, Ruiying Zhang, Man Wang, Man Wang, Man Wang, Yuheng Lang, Yuheng Lang, Jiaqi Zhang, Jiaqi Zhang, Jiaqi Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Han Zheng, Han Zheng, Han Zheng, Yue Zheng, Yue Zheng, Yue Zheng, Yue Zheng, Bingyang Zhou, Bingyang Zhou, Bingyang Zhou   +23 more
doaj   +1 more source

Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. [PDF]

PLoS ONE, 2015
Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cancer cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) and lipoxins (LXs) play a significant role in ...
Chengcheng Zhang, Haining Yu, Xiaofeng Ni, Shengrong Shen, Undurti N Das   +4 more
doaj   +1 more source

Room-temperature air-stable spin transport in bathocuproine-based spin valves [PDF]

, 2013
Organic semiconductors, characterized by weak spin-scattering mechanisms, are attractive materials for those spintronic applications in which the spin information needs to be retained for long times.
Bedoya Pinto, Amilcar, Casanova, Félix, Chuvilin, Andrey, Gobbi, Marco, Golmar, Federico, Hueso, Luis E., Llopis, Roger, Sun, Xiangnan, Txoperena, Oihana   +8 more
core   +1 more source

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source

Control of ALOX5 expression in monocytic cells using a synthetic riboswitch

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
The human 5-lipoxygenase (5-LOX), which is encoded by the arachidonate 5-lipoxygenase (ALOX5) gene, has its canonical function in leukotriene (LT) biosynthesis, which controls inflammatory and allergic responses. Besides oxylipin formation from polyunsaturated fatty acids, 5-LOX has several noncanonical functions.
Robin W, Bruckhoff, Julia H, Oberlis, Dieter, Steinhilber, Beatrix, Suess   +3 more
openaire   +2 more sources

Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5 [PDF]

Scientific Reports, 2017
AbstractDuring the establishment of pregnancy, extravillous trophoblast (EVT) must invade into the uterine decidua to facilitate decidual artery remodelling to create the placental blood supply. The local decidual environment is thought to regulate trophoblast invasion, however these interactions are poorly defined in humans.
Menkhorst, EM, Van Sinderen, ML, Rainczuk, K, Cuman, C, Winship, A, Dimitriadis, E   +5 more
openaire   +4 more sources

Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population

Cellular Physiology and Biochemistry, 2017
Background/Aims: To investigate the roles of the oxidative stress related-genes ALOX5, ALOX5AP and MPO in ischemic stroke susceptibility in the Han Chinese population. Methods: A total of 351 ischemic stroke patients and 417 controls were recruited.
Ding Liu, Lei Liu, Zhi Song, Zhongyang Hu, Jia Liu, Deren Hou   +5 more
doaj   +1 more source

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1548-1565, May 2026.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

Osteomesopyknosis associated with a novel ALOX5 variant that impacts the RANKL pathway

Molecular Genetics & Genomic Medicine
AbstractBackgroundBone tissue homeostasis relies on the coordinated activity of the bone‐forming osteoblasts and bone‐resorbing osteoclasts. Osteomesopyknosis is considered a distinctive rare sclerosing skeletal disorder of unelucidated pathophysiology and presumably autosomal dominant transmission.
Fernández Luna, José Luis, Hernández Hernández, José Luis, Curiel Del Olmo, Soraya, Martínez-Amador, Néstor A., Vega, Ana I., Quirce Pisano, María Remedios, Montes Moreno, Santiago, Gutiérrez, Olga, Real Bolt, Álvaro del, Sañudo Campo, María Carolina, Riancho Moral, José Antonio   +10 more
openaire   +4 more sources

Alox5 Blockade Eradicates JAK2V617F -Induced Polycythemia Vera in Mice [PDF]

Cancer Research, 2017
Abstract Myeloproliferative neoplasms such as polycythemia vera (PV), which are associated with the JAK mutation V617F, remain incurable despite progress in the use of JAK2 inhibitors for treatment of some of these diseases. In this study, we employed mice that undergo JAK2V617F-induced PV as a tool to explore new candidate targets ...
Yaoyu, Chen, Yi, Shan, Min, Lu, Ngoc, DeSouza, Zhiru, Guo, Ronald, Hoffman, Aibin, Liang, Shaoguang, Li   +7 more
openaire   +2 more sources