Results 111 to 120 of about 12,524 (227)

Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5

British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino, Edurne San José‐Enériz, Leire Garate, Estibaliz Miranda, Elena Sáez, Antonio Pineda‐Lucena, Felipe Prósper, Xabier Agirre   +7 more
wiley   +1 more source

In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre‐Clinical Rodent Model

Prenatal Diagnosis, Volume 46, Issue 4, Page 546-555, April 2026.
ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde, Stephanie Finoti, Marc Oria, Jose L. Peiro   +3 more
wiley   +1 more source

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

Mediators of Inflammation, 2010
Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds.
Kathryn P. Burdon, Megan E. Rudock, Allison B. Lehtinen, Carl D. Langefeld, Donald W. Bowden, Thomas C. Register, Yongmei Liu, Barry I. Freedman, J. Jeffrey Carr, Catherine C. Hedrick, Stephen S. Rich   +10 more
doaj   +1 more source

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells [PDF]

, 2012
A therapeutic strategy for treating cancer is to target and eradicate cancer stem cells (CSCs) without harming their normal stem cell counterparts. The success of this approach relies on identification of molecular pathways that selectively regulate CSC ...
Brehm, Michael, Cerny, Jan, Chen, Yaoyu, Green, Michael R., Higgins, Anne, Hu, Yiguo, Hutchinson, Lloyd, Li, Dongguang, Li, Huawei, Li, Shaoguang, Miron, Patricia, Peng, Cong, Sheng, Zhi, Sullivan, Con, Zhang, Haojian, Zhang, Xueqing   +15 more
core   +1 more source

Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms [PDF]

, 2020
Xiao‐Hua Zhou, Yi Jiang, Qiuyun Li, Zhen Huang, Huawei Yang, Changyuan Wei   +5 more
openalex   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Pharmacogenetics of asthma therapeutics [PDF]

, 2016
Asthma is recognised to arise from complex interactions between environmental exposure and disease-susceptibility genetic contributions.1 Pharmacological management of the condition aims to relieve symptoms, decrease airway hyperresponsiveness, and ...
Ellul-Micallef, Roger, Fenech, Anthony G.   +1 more
core  

When Pathways Converge: Iron, Lipid Peroxidation, and α‐Synuclein in Ferroptosis‐Driven Dopaminergic Neurodegeneration

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Dopaminergic neurons are particularly susceptible to ferroptosis. Pacemaking activity–driven calcium (Ca2+) influx increases metabolic demand and reactive oxygen species (ROS) production, promoting iron release from aconitase. Alpha‐synuclein (α‐syn) enhances iron uptake via transferrin receptor 1 (TfR1) and exhibits ferrireductase activity, converting
Carmem L. Sperlich, Brent R. Stockwell, Marcelo Farina   +2 more
wiley   +1 more source

Magnolin alleviated DSS‐induced colitis by inhibiting ALOX5‐mediated ferroptosis

The Kaohsiung Journal of Medical Sciences
AbstractInflammatory bowel disease (IBD) is a chronic and incurable disorder associated with higher cancer risk and currently faces unsatisfactory treatment outcomes. Ferroptotic cells secrete damage‐associated molecular patterns (DAMPs) that recruit and activate immune cells, particularly macrophages.
Ting Yao, Yuan‐Yuan Yao, Jin‐Zhi Wang, Shi‐Man Jiang, Lan‐Juan Li   +4 more
openaire   +3 more sources

Asthma patients with specific genotypes identified for fish oil treatment trial

California Agriculture, 2011
The lifetime prevalence of asthma in California is nearly 20%, and better therapies are needed to manage this common chronic disease. Fish oils containing omega-3 fatty acids are considered a potential therapy for asthma and other inflammatory diseases ...
Hooman Allayee, Cristina Davis, Olga Fortenko, Nicholas J. Kenyon, Gertrud Schuster, Charles Stephensen, Amir Zeki   +6 more
doaj   +2 more sources