Results 131 to 140 of about 12,524 (227)

Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]

, 2019
Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H, Durbin-Johnson, Blythe, Finno, Carrie J, Kang, Mincheol, Lee, Jeong H, Park, Seojin, Perez-Flores, Maria C, Peterson, Janel, Settles, Matthew, Yamoah, Ebenezer N   +9 more
core  

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Anderson, Ashley Hamilton, Bhatia, Bin Zhang, Branford, Carsten Müller-Tidow, Chen, Chomel, Chu, Copland, Corbin, Daley, Druker, Druker, Druker, Elaine K. Allan, Felsher, Franck E. Nicolini, G. Vignir Helgason, Gabert, Gorre, Gothert, Graham, Hamilton, Hayette, Holyoake, Hughes, Hurtz, Jiang, Jordan, Jordanides, Jorgensen, Konig, Konig, Konig, Koschmieder, Li, Lombardo, Lugo, Mirle Schemionek, Myssina, Notta, Pellicano, Ravi Bhatia, Samanta, Samanta, Schemionek, Scott, Shachaf, Shah, Sharma, Sharma, Sobrinho-Simoes, Steffen Koschmieder, Svetlana Myssina, Talpaz, Tessa L. Holyoake, Valerie G. Brunton, Wang, Weinstein, Weisberg, White   +61 more
core   +2 more sources

Pharmacogenetics, pharmacogenomics and airway disease [PDF]

, 2002
The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics.
Hall, Ian P.
core  

Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways

OncoImmunology, 2017
Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising from the metabolic activity of lipoxygenases (ALOX5/15) on ω-6 or ω-3 essential polyunsaturated
Nella Prevete, Federica Liotti, Anna Illiano, Angela Amoresano, Piero Pucci, Amato de Paulis, Rosa Marina Melillo   +6 more
doaj   +1 more source

Supplementary Figure 1 from <i>Alox5</i> Blockade Eradicates <i>JAK2V617F</i>-Induced Polycythemia Vera in Mice

, 2023
Yaoyu Chen, Yi Shan, Min Lü, Ngoc DeSouza, Zhiru Guo, Ronald Hoffman, Aibin Liang, Shaoguang Li   +7 more
openalex   +1 more source

Screening and biomarker assessment of ferroptosis genes FLT3 and ALOX5 in lung adenocarcinoma [PDF]

, 2023
Yuansi Zheng, Ying Su, Lei Ruan, Qingfeng He, Linna Gong, Jieyi Li   +5 more
openalex   +1 more source

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies [PDF]

, 2017
Atherosclerosis constitutes the underlying disease to the clinical manifestations of myocardial infarction, stroke, and gangrene. Despite the success of statins, prevention of clinical events of atherosclerosis remains a major challenge in current-day ...
Hansson, Göran K., Klingenberg, Roland
core  

Structure-Based Virtual Screening for ALOX5 Inhibitors: Combining Scaffold Hopping and Pharmacophore Approaches

Targets
Arachidonic acid 5-lipoxygenase (ALOX5), an enzyme critical for lipid mediator synthesis, demonstrates significant upregulation in clinically distinct disease states. Current research identifies its aberrant activity in neurodegenerative pathologies (e.g.
Xiao Li, Liang Li, Na Zhang, Linxin Wang, Lianxiang Luo   +4 more
doaj   +1 more source

Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets [PDF]

, 2018
Diana Rafael, Fernanda Andrade, Sara Montero‐Herradón, Petra Gener, Joaquin Seras‐Franzoso, Francesc Martínez, Patricia González, Helena F. Florindo, Diego Arango, Joan Sayós, Ibane Abasolo, Mafalda Videira, Simó Schwartz   +12 more
openalex   +1 more source

ALOX5 Gene [PDF]

, 2020
openaire   +1 more source