ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis
Pharmacological Research, 2023 Oxidative disruption of dopaminergic neurons is regarded as a crucial pathogenesis in Parkinson's disease (PD), eventually causing neurodegenerative progression.
Kun Li +12 more
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JMJD3 upregulates ALOX5 to drive malignancy and concomitant ferroptosis sensitivity in gastric cancer [PDF]
Cell Death and DiseaseChemotherapy remains the cornerstone of gastric cancer (GC) treatment, with Oxaliplatin (OXA) being a critical first-line agent. However, chemotherapy resistance, compounded by increased stemness, poses a significant challenge in GC management.
Gege Shu +10 more
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ALOX5 promoter genotype and response to montelukast in moderate persistent asthma [PDF]
Respiratory Medicine, 2008 It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported.Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a
J J Telleria +2 more
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Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice [PDF]
Frontiers in ImmunologyIntroductionEarly-life wheezing-associated respiratory tract infections with rhinovirus (RV) are considered risk factors for asthma development. Cysteinyl leukotrienes (cysLTs) are pro-inflammatory lipid mediators synthesized from arachidonic acid by 5 ...
De’Jana T. Parker +11 more
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Downregulation of Alox5 Inhibits Ferroptosis to Improve Doxorubicin‐Induced Cardiotoxicity via the P53 / SLC7A11 Pathway [PDF]
Journal of Cellular and Molecular MedicineSaiyang Xie, Wei Deng
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Multiomics integrated analysis and experimental validation identify TLR4 and ALOX5 as oxidative stress-related biomarkers in intracranial aneurysms [PDF]
Journal of NeuroinflammationBackground Intracranial aneurysm (IA) is a severe cerebrovascular disease, and effective gene therapy and drug interventions for its treatment are still lacking.
Lvyin Luo +13 more
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Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression [PDF]
Cancer Biology & MedicineObjective: Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer progression. How neutrophils promote lung cancer progression, however, has not been established.
Lulu Han +8 more
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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter [PDF]
Frontiers in Pharmacology5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Marius Hyprath +4 more
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Shenqi Dihuang Decoction Attenuates ALOX5-Mediated Ferroptosis in Diabetic Nephropathy via AMPK/mTOR and TGF-β/Smads Pathways [PDF]
Journal of Diabetes ResearchTo explore the underlying mechanisms about that Shenqi Dihuang decoction (SDD) attenuated diabetic nephropathy (DN), mice were fed on high-sugar and high-fat diet and treated with streptozotocin (STZ) to induce DN model, as well as HK-2 cells treated ...
Li Zhao +4 more
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Irisin regulates lipid metabolism and ferroptosis in ovarian cancer cells by modulating the ALOX5-5-HETE-PD-L1 axis [PDF]
Scientific ReportsThis study investigates the role of arachidonate 5-lipoxygenase (ALOX5) in upregulating programmed death-ligand 1 (PD-L1) expression via its metabolite 5-hydroxyeicosatetraenoic acid (5-HETE) in ovarian cancer cells, and explores the effects on lipid ...
Huichun Cai, Caiyun Huang, Zhenwei Zhang
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