Results 201 to 210 of about 12,524 (227)

Research progress on the mechanism of chondrocyte ferroptosis in osteoarthritis. [PDF]

Front Immunol
Zhou L, Ju S, Wang K, Fu Z, Wu R, He B, Hu Y.   +6 more
europepmc   +1 more source

Towards Precision Treatment of Chronic Obstructive Pulmonary Disease Exacerbations: The Role of Specialized Proresolving Mediators. [PDF]

Am J Respir Crit Care Med
Bon J, Bozinovski S.
europepmc   +1 more source

Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage

Mpotje T, Rajkumar-Bhugeloo K, Moodley D, Nargan K, Lawrence TK, Fisher KL, Maepa SW, Thambu K, Lumamba K, Majozi P, Rapulana AM, Parihar S, Naidoo T, Madansein R, Ndlovu H, Leslie A, Gordon S, Steyn A, Marakalala MJ.   +18 more
europepmc   +1 more source

Association studies of ALOX5 and bone mineral density in healthy adults [PDF]

Osteoporosis International, 2007
Animal studies suggest that arachidonate 5-lipoxygenase (encoded by ALOX5) may be a genetic determinant of bone mineral density. We tested this hypothesis in a sample of healthy men and women and did not find consistent evidence for an association between variation in this gene and either lumbar spine or femoral neck BMD.Phenotypic variation in bone ...
Tatiana Foroud, Howard J Edenberg, Siu Hui   +2 more
exaly   +3 more sources

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ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma

Biochemical Pharmacology, 2023
Melanoma has become more common, and its therapeutic management has remained challenging in recent decades. The purpose of our study is to explore new prognostic therapeutic markers of melanoma and to find new therapeutic methods and therapeutic targets of novel drugs, which have great significance.First, the arachidonate 5-lipoxygenase (ALOX5) gene ...
Xiaobin Zhu
exaly   +3 more sources

mPGES-1 and ALOX5/-15 in tumor-associated macrophages

Cancer and Metastasis Reviews, 2018
The tumor immune landscape gained considerable interest based on the knowledge that genetic aberrations in cancer cells alone are insufficient for tumor development. Macrophages are basically supporting all hallmarks of cancer and owing to their tremendous plasticity they may exert a whole spectrum of anti-tumor and pro-tumor activities. As part of the
Andreas, Weigert, Elisabeth, Strack, Ryan G, Snodgrass, Bernhard, Brüne   +3 more
openaire   +2 more sources

[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].

Zhongguo shi yan xue ye xue za zhi, 2020
To investigate the correlation of single nucleotide polymorphisms (SNP) in arachidonate 5-lipoxygenase gene (ALOX5) rs2029253, rs2228064 and rs2228065 sites, 5-lipoxygenase activating protein gene (ALOX5AP) rs10507391, rs4769874 sites with the risk for genesis of adult myeloid leukemia.By the approval from the hospital ethics committee and the informed
Fen, Mei, Yan-Fei, Wang, Dan, Yang, Rong-Xia, Zuo, Tao, Shen, Tong-Hua, Yang, Ya-Lian, Sa   +6 more
openaire   +2 more sources

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

Nature Genetics, 1999
Clinically similar asthma patients may develop airway obstruction by different mechanisms. Asthma treatments that specifically interfere with the 5-lipoxygenase (ALOX5) pathway provide a method to identify those patients in whom the products of the ALOX5 pathway (that is, the leukotrienes) contribute to the expression of the asthma phenotype.
Eric S Silverman, David A Katz, Jeffrey M Dražen   +2 more
exaly   +3 more sources