Identification of Key Targets of Herbal Compounds for Liver Fibrosis Using Network Pharmacology Combined With Transcriptomics [PDF]
Gastroenterology Research and PracticeChinese herbal compound prescriptions have demonstrated efficacy in preventing and treating liver fibrosis (LF), though their mechanisms remained unclear.
Chen Chen +5 more
doaj +2 more sources
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics [PDF]
The FEBS Journal, 2020 5‐Lipoxygenase (5‐LO) is the initial enzyme in the biosynthesis of leukotrienes, which are mediators involved in pathophysiological conditions such as asthma and certain cancer types. Knowledge of proteins involved in 5‐LO pathway regulation, including gene regulatory proteins, is needed to evaluate all options for therapeutic intervention in these ...
Katharina Schlag +3 more
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Annals of MedicinePurpose This study investigated the molecular mechanism of quercetin in the treatment of sepsis using network pharmacological prediction and experimentation.Methods Hub genes were identified by intersecting the differentially expressed genes (DEGs) of ...
Chu-Yun Liu +6 more
doaj +2 more sources
Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis [PDF]
PharmaceuticalsBackground: Fructus Meliae Toosendan (FMT) is a traditional Chinese medicine used to treat ascariasis; however, its reported hepatotoxicity limits its application.
Jiajie Ni +6 more
doaj +2 more sources
Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway [PDF]
Journal of Biological Chemistry, 2013 Ting Xi Liu
exaly +2 more sources
Identification of ALOX5 as a gene regulating adiposity and pancreatic function [PDF]
Diabetologia, 2008 We previously used an integrative genetics approach to demonstrate that 5-lipoxygenase (5-LO) deficiency in mice (Alox5 (-/-)) protects against atherosclerosis despite increasing lipid levels and fat mass. In the present study, we sought to further examine the role of 5-LO in adiposity and pancreatic function.Alox5 (-/-) and wild-type (WT) mice were ...
Margarete Mehrabian +9 more
openalex +4 more sources
Scientific ReportsDiabetic kidney disease (DKD) is a leading cause of renal failure. Inflammation of the renal tubules and interstitium is a critical factor in the progression of DKD; however, the key regulatory genes and characteristics of the immune microenvironment ...
Wei Lu +18 more
doaj +2 more sources
LncRNA PVT1 Facilitates Phenotypic Switching of Vascular Smooth Muscle Cells in Intracranial Aneurysms by Recruiting KDM1A to Reduce H3K9me2 Modification [PDF]
Kaohsiung Journal of Medical SciencesThis study explores the differential expression of lncRNA PVT1 in intracranial aneurysms (IAs) and its role in the phenotypic switching of vascular smooth muscle cells (VSMCs).
Yu‐Fei Cheng +4 more
doaj +2 more sources
Tumoral ALOX5 mediated arachidonic acid metabolism regulates immune response in non-small cell lung cancer. [PDF]
Cell Oncol (Dordr)Gao Y +10 more
europepmc +3 more sources