Results 31 to 40 of about 12,524 (227)

Transcriptome Analysis of Leg Muscles and the Effects of ALOX5 on Proliferation and Differentiation of Myoblasts in Haiyang Yellow Chickens [PDF]

Genes, 2023
Jinyu Wang
exaly   +2 more sources

Ipriflavone From <i>Aquilaria malaccensis</i> Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviating Hypoxia-Induced Gastrointestinal Mucosal Ferroptosis. [PDF]

MedComm (2020)
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Wang D, Liao X, Wang Y, Wang X, Zhang H, Zeng J, Zhang M, Wang X, Ren F, Wang Y, Li M, Wang W, Lin Q, Gu L, Chang Z, Sheng J.   +15 more
europepmc   +2 more sources

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodelingResearch in context

EBioMedicine, 2022
Summary: Background: Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis.
Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang   +14 more
doaj   +1 more source

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5

ACS Chemical Biology, 2019
For the specificity of ALOX15 orthologs of different mammals, the geometry of the amino acids Phe353, Ile418, Met419, and Ile593 ("triad determinants") is important, and mutagenesis of these residues altered the reaction specificity of these enzymes. Here we expressed wild-type human ALOX5 and its F359W/A424I/N425M/A603I mutant in Sf9 insect cells and ...
Igor Ivanov, Alexey Golovanov, Cristián A. Ferretti, Miquel Canyelles-Niño, Dagmar Heydeck, Sabine Stehling, José M. Lluch, Àngels González‐Lafont, Hartmut Kühn   +8 more
openalex   +4 more sources

Predicting the clinical prognosis of non-small cell lung cancer patients by predicting ALOX5 expression: a radiomics model. [PDF]

J Thorac Dis
Hu P, Liu M, Gu H, Liu H, Li Q, Tian B.
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

ALOX5 (arachidonate 5-lipoxygenase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
S Banerjee, S Tuncay
openaire   +1 more source

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source

Alox5 activation in the blood of humans with high CRP.

We measured total transcription in the blood in humans with low CRP and in humans with high CRP to identify causative factors in cardiovascular disease mediated by inflammation. We describe here activation of Alox5 in humans with high CRP.  
Mamoor, Shahan
openalex   +2 more sources

ALOX5 variants associated with susceptibility to human pulmonary tuberculosis [PDF]

Human Molecular Genetics, 2007
The 5-lipoxygenase (ALOX5)-derived lipid mediators leukotrienes and lipoxins have regulatory functions in inflammation by modulating activities of immune cells and cytokine production. Recently, it was shown in ALOX5-/- mice that host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase (5-LO). ALOX5 polymorphisms were genotyped in 1916
Florian, Herb, Thorsten, Thye, Stefan, Niemann, Edmund N L, Browne, Margaret A, Chinbuah, John, Gyapong, Ivy, Osei, Ellis, Owusu-Dabo, Oliver, Werz, Sabine, Rüsch-Gerdes, Rolf D, Horstmann, Christian G, Meyer   +11 more
openaire   +2 more sources