ALOX5 Is Associated with Tuberculosis in a Subset of the Pediatric Population of North China [PDF]
Genetic Testing and Molecular Biomarkers, 2013 Background: Genetic factors are involved in the etiology of Mycobacterium tuberculosis infection. Recently, ALOX5 has been identified as a candidate gene for tuberculosis (TB) susceptibility.
Chen, Shen +12 more
openaire +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐
Hyun‐Jun Kim +4 more
doaj +1 more source
Prevalence of common disease-associated variants in Asian Indians [PDF]
, 2008 Background Asian Indians display a high prevalence of diseases linked to changes in diet and environment that have arisen as their lifestyle has become more westernized.
Trevor J Pemberton +6 more
core +1 more source
Prediction of pEC50(M) and molecular docking study for the selective inhibition of arachidonate 5-lipoxygenase [PDF]
The Ukrainian Biochemical Journal, 2021 Arachidonate 5-lipoxygenase (ALOX5) is considered a prime target for drug discovery in the area of liver fibrosis, rheumatoid arthritis, atherosclerosis, cancer and asthma.
N. R. Das, P. G. R. Achary
doaj +1 more source
Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. [PDF]
, 2016 Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke, we tested whether elevating blood miR-122 would improve stroke outcomes in rats.
Ander, Bradley P +9 more
core +2 more sources
Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Stroke among Patients with Hypertension [PDF]
, 2020 Background: Dysregulations ofAQP7andAQP9were found to be related to lipid metabolism abnormality, which had been provento be one of the mechanisms of stroke. However, limited epidemiological studies explore the associations betweenAQP7andAQP9and the risk
Cui, Lan +6 more
core +2 more sources
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]
, 2013 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P. +6 more
core +2 more sources
Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]
, 2013 Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
core +4 more sources
Effect and Mechanism of Acacetin Against Stress-Induced Gastric Mucosal Damage: Network Pharmacology, Molecular Docking and Experimental Verification. [PDF]
Food Sci NutrThis study evaluated Acacetin's therapeutic potential for stress‐induced gastric mucosal damage and investigated its potential mechanism. Based on network pharmacology and molecular docking, Acacetin demonstrated potential mucosal protective effects through multiple ferroptosis‐related targets.
Zhang XX +7 more
europepmc +2 more sources
AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer [PDF]
, 2016 Background Building up of pathway-/disease-relevant signatures provides a persuasive tool for understanding the functional relevance of gene alterations and gene network associations in multifactorial human diseases.
Birner, Peter +17 more
core +2 more sources