Genetic basis for personalized medicine in asthma [PDF]
, 2012 There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic ...
Asano +76 more
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The functional analysis for the association of ALOX5 polymorphisms with asthma
The FASEB Journal, 2008 The leukotrienes constitute a group of arachidonic acid‐derived compounds suggesting important roles in inflammation and immediate hypersensitivity. ALOX5 is a key enzyme required for the production of the cysteinyl‐leukotrienes. We genotyped five SNPs among these polymorphisms in a Korean population.
Hun‐Soo Chang +7 more
openaire +1 more source
PLoS ONE, 2014 Pulmonary Hypertension (PH) is a progressive disorder characterized by endothelial dysfunction and proliferation. Hypoxia induces PH by increasing vascular remodeling. A potential mediator in hypoxia-induced PH development is arachidonate 5-Lipoxygenase (
Kristi M Porter +5 more
doaj +1 more source
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]
, 2018 Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus +2 more
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HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population. [PDF]
, 2018 BACKGROUND: Higher prevalence of atherosclerosis and higher cardiovascular risk is observed in HIV-infected individuals. The biological mechanisms underlying these processes are unclear.
Arranz, María Jesús +10 more
core +1 more source
Molecular epidemiology of Mycobacterium africanum in Ghana [PDF]
, 2016 BACKGROUND: Mycobacterium africanum comprises two phylogenetic lineages within the M. tuberculosis complex (MTBC) and is an important cause of human tuberculosis (TB) in West Africa. The reasons for this geographic restriction of M.
Ahorlu, Collins +13 more
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Evaluation of cerebrospinal fluid levels for ALOX5, S100B, DEFA1, and GFAP in infectious meningitis
Medicine, 2023 Background: The aim of this study was to determine how the levels of peptide and protein-based biomarkers in cerebrospinal fluid change in bacterial, tuberculous, and aseptic meningitis, and to determine the success of these agents in distinguishing between different types of infectious meningitis.
Baran, Ali İrfan +8 more
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Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. [PDF]
PLoS ONE, 2011 The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia.
Zhigang Xie +8 more
doaj +1 more source
Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium (48Ti) Ions [PDF]
, 2015 Myeloid leukemia (ML) is one of the major health concerns from exposure to radiation. However, the risk assessment for developing ML after exposure to space radiation remains uncertain.
Gordon, Chris +6 more
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Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia. [PDF]
PLoS Genetics, 2013 Fusion protein RUNX1-ETO (AML1-ETO, RUNX1-RUNX1T1) is expressed as the result of the 8q22;21q22 translocation [t(8;21)], which is one of the most common chromosomal abnormalities found in acute myeloid leukemia.
Russell C DeKelver +7 more
doaj +1 more source