Results 71 to 80 of about 12,524 (227)
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
A High-Fat Diet Induces Bone Loss in Mice Lacking the Alox5 Gene [PDF]
Endocrinology, 2012 5-Lipoxygenase catalyzes leukotriene generation from arachidonic acid. The gene that encodes 5-lipoxygenase, Alox5, has been identified in genome-wide association and mouse Quantitative Trait Locus studies as a candidate gene for obesity and low bone mass.
Phuong, Le +5 more
openaire +2 more sources
Renal Failure, 2023 Diabetic nephropathy (DN) is the primary complication of diabetes mellitus. Ferroptosis is a form of cell death that plays an important role in DN tubulointerstitial injury, but the specific molecular mechanism remains unclear. Here, we downloaded the DN
Li-Li Ma +3 more
doaj +1 more source
Dynamical depinning of chiral domain walls [PDF]
, 2017 The domain wall depinning field represents the minimum magnetic field needed to move a domain wall, typically pinned by samples' disorder or patterned constrictions.
Martinez, Eduardo +2 more
core +3 more sources
Animal Research and One Health, EarlyView.Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian +8 more
wiley +1 more source
Proteins interaction network and modeling of IGVH mutational status in chronic lymphocytic leukemia [PDF]
, 2015 BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B-lymphocytes, characterized as being a heterogeneous disease with variable clinical manifestation and survival.
Andrés Fernando González Barrios +3 more
core +1 more source
Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]
, 2019 Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core
Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems [PDF]
, 2011 Background Understanding host response to influenza virus infection will facilitate development of better diagnoses and therapeutic interventions.
Jason E McDermott +10 more
core +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundThe arachidonate 5‐lipoxygenase enzyme plays a crucial role in mediating inflammation to maintain homeostasis, yet certain allelic variants of the 5‐lipoxygenase gene, ALOX5, may increase risk of atherosclerosis and coronary heart disease (CHD).
Michael Y. Tsai +6 more
doaj +1 more source