Results 41 to 50 of about 2,952 (190)

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

A Generalizable Framework for Building Executable Domain‐Specific Large Language Models Under Data Scarcity: Demonstration on Semiconductor Technology Computer‐Aided Design Simulation

Advanced Intelligent Systems, EarlyView.
A schema‐first alignment framework builds compact, executable domain‐specific language models under data scarcity. Large‐scale synthetic question‐answer generation instills domain knowledge, and a code‐centric IR‐to‐DPO pipeline aligns generation with tool‐executable syntax.
Di Wang, Zhenhua Wu, Yu Liu, Kai Chang, Shaohua Wu   +4 more
wiley   +1 more source

Parasitism-Induced Changes in Microbial Eukaryotes of Peruvian Alpaca Gastrointestinal Tract

Life
Alpacas, important genetic resources in the Andean region of Peru, are vulnerable to diarrhea caused by pathogenic parasites such as Eimeria lamae and Giardia sp., which can be fatal, especially in neonates, due to their physiological immaturity and ...
Diana Sanchez, Celso Zapata, Yolanda Romero, Nils H. Flores-Huarco, Oscar Oros, Wigoberto Alvarado, Carlos Quilcate, Hada M. Guevara-Alvarado, Richard Estrada, Pedro Coila   +9 more
doaj   +1 more source

Transition Metal Compounds as Thermochromic Materials: Classification, Properties, Limitations, and Applications

EcoEnergy, EarlyView.
This review systematically examines how different transition metal compounds—such as binary and multinary metal oxides, halides, sulfides, and salts—exhibit thermochromism based on the d‐electron configurations of their transition metal cations. It focuses on three main mechanisms of thermochromism: phase transition, charge transfer, and bandgap change.
Jie Wang, Shan Wang, Long Yuan, Ling Zuo, Hui Qi, Changmin Hou   +5 more
wiley   +1 more source

Using Real-Time GNSS Tracking Tags to Monitor Alpaca Activity in an Australian Extensive Production System

Agriculture
Australian alpacas contribute to a developing alternative fibre industry with an increasing number of larger-scale enterprises requiring real-time management options.
Imogen Boughey, Evelyn Hall, Russell Bush   +2 more
doaj   +1 more source

Divergent Genotype of Hepatitis A Virus in Alpacas, Bolivia, 2019

Emerging Infectious Diseases, 2023
Hepatitis A virus (HAV) is a common human pathogen found exclusively in primates. In a molecular and serologic study of 64 alpacas in Bolivia, we detected RNA of distinct HAV in ≈9% of animals and HAV antibodies in ≈64%.
Talitha Veith, L. Fabian Beltran-Saavedra, Tobias Bleicker, Marie Luisa Schmidt, José L. Mollericona, Kim Grützmacher, Rob Wallace, Jan Felix Drexler, Christian Walzer, Terry C. Jones, Christian Drosten, Victor Max Corman   +11 more
doaj   +1 more source

Modeling the impacts of grazing management on livestock behavior and performance: A case study in the Peruvian Andes

Grassland Research, EarlyView.
Our modeling study shows that livestock management strongly influences grazing behavior and animal performance in the Peruvian Andes. Furthermore, adjusting stocking rates and improving animal distribution can enhance forage intake and body condition while increasing forage biomass.
Melody R. Zarria Samanamud, Randall B. Boone   +1 more
wiley   +1 more source

Evaluation of a non‐radioactive rapid test for determination of serum progesterone in South American camelids

Veterinary Record, EarlyView.
Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer, Gerhard Schuler, Philipp Pohlscheid, Henrik Wagner, Kathrin Büttner, Axel Wehrend   +5 more
wiley   +1 more source

A Literature Review of Selected Bacterial Diseases in Alpacas and Llamas—Epidemiology, Clinical Signs and Diagnostics

Animals, 2023
The breeding of South American Camelids (SACs), particularly llamas and alpacas, is becoming increasingly popular in regions that are not their natural habitat, including Europe. These animals are considered to be relatively disease resistant.
Kacper Konieczny, Małgorzata Pomorska-Mól   +1 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source