Results 41 to 50 of about 19,739 (203)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Parasitism-Induced Changes in Microbial Eukaryotes of Peruvian Alpaca Gastrointestinal Tract

Life
Alpacas, important genetic resources in the Andean region of Peru, are vulnerable to diarrhea caused by pathogenic parasites such as Eimeria lamae and Giardia sp., which can be fatal, especially in neonates, due to their physiological immaturity and ...
Diana Sanchez, Celso Zapata, Yolanda Romero, Nils H. Flores-Huarco, Oscar Oros, Wigoberto Alvarado, Carlos Quilcate, Hada M. Guevara-Alvarado, Richard Estrada, Pedro Coila   +9 more
doaj   +1 more source

Relationships between skin follicle characteristics and fibre properties of Suri and Huacaya alpacas and Peppin Merino sheep

, 2012
We aimed to quantify the number, type and arrangement of skin follicles in Huacaya and Suri alpaca skin and correlate their follicle characteristics with fibre traits of harvested fibre and compared these relationships with those of Merino sheep.
Behrendt, R., Ferguson, M. B., McGregor, B. A.   +2 more
core   +1 more source

Caracterización de IgM, IgG Total, IgG1 y anticuerpos de cadena pesada en calostro de llamas ("Lama glama") mediante Elisa [PDF]

, 2014
Objectives: to determine the levels of IgM, total IgG, IgG1 and HCAbs (IgG2 and IgG3) in colostra of llamas and to evaluate the concentration of HCAbs in relation to total IgG and the conventional isotype IgG1.
Caggiano, Nicolás, Chiappe Barbará, María Angelina, De Simone, Emilio, Gentile, Teresa, Leoni, Juliana, Saccodossi, Natalia   +5 more
core   +2 more sources

Thrombotic Endocarditis in 10 Alpacas [PDF]

Journal of Veterinary Internal Medicine, 2008
Background:A description of the clinical signs and necropsy findings in 10 alpacas with thrombotic endocarditis.Animals:Clinical cases admitted to 2 veterinary referral hospitals between May 1998 and December 2006.Methods:A retrospective study was performed by searching hospital records to identify alpacas diagnosed with endocarditis.Results:Common ...
A M, Firshman, A, Wünschmann, C K, Cebra, R, Bildfell, S L, McClanahan, B A, Valentine, E, McKenzie, L, Waitt, M, Margiocco, D D, Sisson   +9 more
openaire   +2 more sources

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, EarlyView.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Using Real-Time GNSS Tracking Tags to Monitor Alpaca Activity in an Australian Extensive Production System

Agriculture
Australian alpacas contribute to a developing alternative fibre industry with an increasing number of larger-scale enterprises requiring real-time management options.
Imogen Boughey, Evelyn Hall, Russell Bush   +2 more
doaj   +1 more source

Ovulation-inducing factor: a protein component of llama seminal plasma [PDF]

, 2010
Background Previously, we documented the presence of ovulation-inducing factor (OIF) in the seminal plasma of llamas and alpacas. The purpose of the study was to define the biochemical characteristics of the molecule(s) in seminal plasma responsible for ...
Marcelo H Ratto, Wilfredo Huanca, Gregg P Adams   +2 more
core   +2 more sources

Malignant Neoplasia in Four Alpacas [PDF]

Journal of Veterinary Diagnostic Investigation, 2004
Malignant neoplasia in 4 alpacas was characterized by acute onset of clinical signs and rapidly deteriorating condition. Postmortem examination revealed metastatic or multicentric neoplasia in the abdominal organs of alpacas 1, 3, and 4 and an extensive thoracic mass in alpaca 2.
Eva A, Sartin, D Ralph, Crowe, Elizabeth M, Whitley, Robert E, Treat, Stephen R, Purdy, Ellen B, Belknap   +5 more
openaire   +2 more sources