Results 21 to 30 of about 459,657 (249)

Alpha-1 antitrypsin deficiency [PDF]

Archives of Disease in Childhood, 2001
α-1 antitrypsin is synthesised in the liver and protects lung alveolar tissues from destruction by neutrophil elastase. α-1 antitrypsin deficiency is a common autosomal recessive condition (1:1600 to 1:1800) in which liver disease results from retention of abnormal polymerised α-1 antitrypsin in the endoplasmic reticulum of hepatocytes, and emphysema ...
Primhak, R.A., Tanner, M.S.
openaire   +4 more sources

Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. [PDF]

PLoS ONE, 2014
The human serine protease high temperature requirement A1 (HTRA1) is highly expressed in the placental tissue, especially in the last trimester of gestation. This suggests that HTRA1 is involved in placental formation and function.
Violette Frochaux, Diana Hildebrand, Anja Talke, Michael W Linscheid, Hartmut Schlüter   +4 more
doaj   +1 more source

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

bioRxiv, 2020
Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial.
N. Azouz, Andrea M. Klingler, V. Callahan, I. Akhrymuk, Katarina Elez, L. Raich, B. Henry, J. Benoit, S. Benoit, F. Noé, K. Kehn-Hall, M. Rothenberg   +11 more
semanticscholar   +1 more source

The undiagnosed disease burden associated with alpha-1 antitrypsin deficiency genotypes

European Respiratory Journal, 2020
Alpha-1 antitrypsin deficiency (AATD), mainly due to the PI*ZZ genotype in SERPINA1, is one of the most common inherited diseases. Since it is associated with a high disease burden and partially prevented by smoking cessation, identification of PI*ZZ ...
T. Nakanishi, Vincenzo Forgetta, T. Handa, T. Hirai, V. Mooser, G. Lathrop, W. Cookson, J. B. Richards   +7 more
semanticscholar   +1 more source

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD

Multidisciplinary Respiratory Medicine, 2017
Background Alpha-1-antitrypsin deficiency (AATD) is an under-diagnosed condition in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to screen for AATD in Kazakh patients with COPD using dried blood spot specimens ...
Ardak Zhumagaliyeva, Stefania Ottaviani, Timm Greulich, Marina Gorrini, Claus Vogelmeier, Ludmila Karazhanova, Gulmira Nurgazina, Annalisa DeSilvestri, Victor Kotke, Valentina Barzon, Michele Zorzetto, Angelo Corsico, Ilaria Ferrarotti   +12 more
doaj   +1 more source

Alpha‐1‐antitrypsin: A possible host protective factor against Covid‐19

Reviews in Medical Virology, 2020
Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties.
Mariana Braccialli de Loyola, Thaís dos Reis, Guilherme Xavier Lyra Malcher de Oliveira, Julys da Fonseca Palmeira, G. A. Argañaraz, E. Argañaraz   +5 more
semanticscholar   +1 more source

Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein

International Journal of Molecular Sciences, 2020
Alpha-1-antitrypsin (AAT), an acute-phase protein encoded by the SERPINA1 gene, is a member of the serine protease inhibitor (SERPIN) superfamily. Its primary function is to protect tissues from enzymes released during inflammation, such as neutrophil ...
U. Lechowicz, S. Rudziński, A. Jezela-Stanek, S. Janciauskiene, J. Chorostowska-Wynimko   +4 more
semanticscholar   +1 more source

Clarifying the relationship between pulmonary langerhans cell histiocytosis and Alpha 1 antitrypsin deficiency

Orphanet Journal of Rare Diseases, 2021
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking related, progressive diffuse cystic lung disease that occurs primarily in smokers. The aim of this study was to determine if there was an increase in alpha-1 antitrypsin deficient alleles ...
Cormac McCarthy, Emmanuelle Bugnet, Amira Benattia, Michael P. Keane, Benoit Vedie, Gwenaël Lorillon, Abdellatif Tazi   +6 more
doaj   +1 more source

Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19

Medical Hypotheses, 2020
No definitive treatment for COVID-19 exists although promising results have been reported with remdesivir and glucocorticoids. Short of a truly effective preventive or curative vaccine against SARS-CoV-2, it is becoming increasingly clear that multiple
X. Bai, Joseph A. Hippensteel, Alida O Leavitt, J. Maloney, David Beckham, Cindy Garcia, Q. Li, Brian M. Freed, D. Ordway, R.A. Sandhaus, E. Chan   +10 more
semanticscholar   +1 more source

PROINFLAMMATORY CYTOKINE PROFILE IN PATIENTS WITH DIFFERENT ALPHA-1-ANTITRYPSIN PHENOTYPES

Медицинская иммунология, 2016
Alpha-1-antitrypsin (A1AT) exerts a wide spectrum of protective effects, being focused on reduction of secondary injury in inflammation. Moreover, A1AT inhibits some serine proteases, and down-regulates production of proinflammatory cytokines.
M. Yu. Pervakova, S. V. Lapin, E. A. Surkova, O. Yu. Tkachenko, A. I. Budkova, V. I. Guseva, O. N. Titova, V. L. Emanuel, Areg A. Totolian   +8 more
doaj   +1 more source