Results 31 to 40 of about 410,523 (291)

Alpha‐1‐antitrypsin: A possible host protective factor against Covid‐19

Reviews in Medical Virology, 2020
Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties.
Mariana Braccialli de Loyola, Thaís Tereza Aguiar Dos Reis, Guilherme Xavier Lyra Malcher de Oliveira, Julys da Fonseca Palmeira, G. A. Argañaraz, E. Argañaraz   +5 more
semanticscholar   +1 more source

Clarifying the relationship between pulmonary langerhans cell histiocytosis and Alpha 1 antitrypsin deficiency

Orphanet Journal of Rare Diseases, 2021
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking related, progressive diffuse cystic lung disease that occurs primarily in smokers. The aim of this study was to determine if there was an increase in alpha-1 antitrypsin deficient alleles ...
Cormac McCarthy, Emmanuelle Bugnet, Amira Benattia, Michael P. Keane, Benoit Vedie, Gwenaël Lorillon, Abdellatif Tazi   +6 more
doaj   +1 more source

Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco [PDF]

, 2001
The program at this year's American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lung inflammation, namely leukocyte recruitment ...
Woolhouse Ian
core   +2 more sources

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis [PDF]

, 2020
Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening.
Carreto, Luis, Chalmers, James D., Donovan, Jackie, Fardon, Tom, Finch, Simon, Furrie, Elisabeth, Loebinger, Michael, Morrison, Meghan, Tan, Gan Liang, Wilson, Robert   +9 more
core   +3 more sources

Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein

International Journal of Molecular Sciences, 2020
Alpha-1-antitrypsin (AAT), an acute-phase protein encoded by the SERPINA1 gene, is a member of the serine protease inhibitor (SERPIN) superfamily. Its primary function is to protect tissues from enzymes released during inflammation, such as neutrophil ...
U. Lechowicz, S. Rudziński, A. Jezela-Stanek, S. Janciauskiene, J. Chorostowska-Wynimko   +4 more
semanticscholar   +1 more source

PROINFLAMMATORY CYTOKINE PROFILE IN PATIENTS WITH DIFFERENT ALPHA-1-ANTITRYPSIN PHENOTYPES

Медицинская иммунология, 2016
Alpha-1-antitrypsin (A1AT) exerts a wide spectrum of protective effects, being focused on reduction of secondary injury in inflammation. Moreover, A1AT inhibits some serine proteases, and down-regulates production of proinflammatory cytokines.
M. Yu. Pervakova, S. V. Lapin, E. A. Surkova, O. Yu. Tkachenko, A. I. Budkova, V. I. Guseva, O. N. Titova, V. L. Emanuel, Areg A. Totolian   +8 more
doaj   +1 more source

Alpha-1 Antitrypsin Deficiency: Principles of Care

Acta Médica Portuguesa, 2020
Alpha-1 antitrypsin deficiency is an autosomal co-dominant inherited disorder that results in decreased circulating levels of alpha-1 antitrypsin (also known as alpha-1 proteinase inhibitor) and predisposes affected individuals to early onset lung and ...
Joana F. Rodrigues, Alexandra Mineiro, António Reis, David G. Ventura, Fernando Fernandez-Llimos, Filipa Costa, Joana Gomes, José Manuel Silva, Paulo Lopes, Carlos Robalo Cordeiro   +9 more
doaj   +1 more source

Ethnic differences in alpha‐1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID‐19 fatality rates

The FASEB Journal, 2020
Infection rates, severity, and fatalities due to COVID‐19, the pandemic mediated by SARS‐CoV‐2, vary greatly between countries. With few exceptions, these are lower in East and Southeast Asian and Sub‐Saharan African countries compared with other regions.
G. Shapira, N. Shomron, D. Gurwitz
semanticscholar   +1 more source

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]

, 2014
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo, Gallo, Juan Eduardo Maria, Ortiz, Gustavo Alfredo, Salica, Juan Pablo   +3 more
core   +1 more source

Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease.

JCI Insight, 2020
Autosomal co-dominant genetic disorder alpha-1 antitrypsin (AAT) deficiency (AATD) causes pulmonary and liver disease. Individuals homozygous for the mutant Z allele accumulate polymers of Z-AAT protein in hepatocytes, where AAT is primarily produced ...
C. Wooddell, K. Blomenkamp, Ryan M. Peterson, V. Subbotin, C. Schwabe, J. Hamilton, Q. Chu, D. Christianson, J. Hegge, J. Kolbe, H. Hamilton, M. Branca-Afrazi, B. Given, D. Lewis, E. Gane, S. Kanner, J. Teckman   +16 more
semanticscholar   +1 more source