Results 41 to 50 of about 46,559 (266)

Purification and characterization of an alpha-galactosidase from Aspergillus fumigatus

Brazilian Archives of Biology and Technology, 2005
Aspergillus fumigatus secreted invertase (beta-fructofuranosidase) and alpha-galactosidase enzymatic activities able to hydrolyzing raffinose oligosaccharides (RO).
Sebastião Tavares de Rezende, Valéria Monteze Guimarães, Marília de Castro Rodrigues, Carlos Roberto Felix   +3 more
doaj   +1 more source

Genetically Modified Cell Transplantation Through Macroencapsulated Spheroids with Scaffolds to Treat Fabry Disease

Cell Transplantation, 2021
Cell transplantation is expected to be another strategy to treat lysosomal diseases, having several advantages compared to enzyme replacement therapy, such as continuous enzyme secretion and one-time treatment to cure diseases.
Daisuke Kami, Yosuke Suzuki, Masashi Yamanami, Takahiro Tsukimura, Tadayasu Togawa, Hitoshi Sakuraba, Satoshi Gojo   +6 more
doaj   +1 more source

Purificação e caracterização de alfa-galactosidases de sementes de Platymiscium pubescens Micheli Purification and characterization of alpha-galactosidases from Platymiscium pubescens Micheli seeds

Revista Árvore, 2005
Este trabalho objetivou foi determinar a composição bioquímica de sementes de espécies florestais e caracterizar a enzima alfa-galactosidase de sementes germinadas de Platymiscium pubescens. Os maiores teores de lipídios foram determinados em sementes de
Giordani de Oliveira, Valéria Monteze Guimarães, Eduardo Euclydes de Lima e Borges, Lilian da Silva Fialho, Maria Goreti de Almeida e Oliveira, Sebastião Tavares de Rezende   +5 more
doaj   +1 more source

.ALPHA.-Galactosidase of alkalophilic microorganisms. I. Identification and growth characteristics of .ALPHA.-galactosidase-producing microorganisms.

Agricultural and Biological Chemistry, 1976
Two kinds of α-galactosidase-producing microorganisms, strain No. 31–2 and strain No. 7–5, have been isolated from soil and subjected to a determinative study. On the basis of the morphological and physiological characters, the strain No. 31–2 was identified to be belonged to genus Micrococcus and the strain No. 7–5 to genus Bacillus. The former strain,
Teruhiko AKIBA, Koki HORIKOSHI
openaire   +2 more sources

Fabry's disease manifesting as familial angiokeratoma corporis diffusum in an indian family – A rare occurrence!

Indian Journal of Paediatric Dermatology, 2020
Fabry's disease is a rare X-linked dermatosis, resulting from alpha-galactosidase deficiency and presents with both cutaneous (angiokeratoma, acral paresthesia, and hypohidrosis) and extracutaneous manifestations (ocular, cardiac, renal, and neurological)
Ishmeet Kaur, Archana Singal, Deepak Jakhar, Deepika Pandhi   +3 more
doaj   +1 more source

The validation of pharmacogenetics for the identification of Fabry patients to be treated with migalastat [PDF]

, 2017
PURPOSE: Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene. Migalastat, a pharmacological chaperone, binds to specific mutant forms of α-galactosidase A to restore lysosomal activity.
A Gal, AK Topaloglu, Benjamin Bronfin, C Filoni, Carrolee Barlow, CM Eng, Daniel G. Bichet, David J. Lockhart, Derralynn Hughes, Dominique P. Germain, DP Germain, DP Germain, DP Germain, DP Germain, E Conzelmann, Elfrida R. Benjamin, ER Benjamin, Evan Katz, Farhana Pruthi, FK Johnson, G Altarescu, GH Yam, GH Yam, Hadis Williams, J Lukas, J Shabbeer, Jay Barth, Jeff Castelli, John Kirk, JQ Fan, Julie Yu, Kenneth J. Valenzano, L Barisoni, L Echevarria, M Ries, Maria Cecilia Della Valle, MJ van Breemen, P Lemansky, R Giugliani, R Khanna, Raphael Schiffmann, RJ Desnick, RJ Desnick, RO Brady, Robert J. Desnick, Roberto Giugliani, S Ishii, Sarah Bond, SH Shin, SM Rombach, William R. Wilcox, WR Wilcox, X Wu, Xiaoyang Wu   +53 more
core   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Cloning and characterization of a chickpea α-galactosidase befitting industrial bioprocess applications

Discover Applied Sciences
Chickpea (Cicer arietinum) contains at least four alpha-galactosidase genes (LOC101512744, LOC101513035, LOC101503593, and LOC101502309). The alpha-galactosidase gene (LOC101513035) was isolated from chickpea, cloned as eGFP fusion in pET 15b-eGFP, and ...
P. M. Vetriselvi, Marcus Samuel, Rex Arunraj   +2 more
doaj   +1 more source

Diagnostics of Fabry disease in arrhythmology practice: a case report

Российский кардиологический журнал, 2022
Heart failure in Fabry disease (FD) is unfavorable prognostic manifestation and cause of death. Given that the disease is rare in clinical practice, the low awareness of physicians about this pathology leads to its late diagnosis and the lack of ...
M. A. Dragunova, I. V. Kisteneva, E. N. Pavlyukova, L. P. Nazarenko, S. V. Popov   +4 more
doaj   +1 more source

A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report [PDF]

, 2012
Background: Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids
Albeggiani, G, ALESSANDRO, Riccardo, COLOMBA, Paolo, Duro, G., Iemolo, F, Imbraco, M, Pisani, A, Zizzo, Carmela   +7 more
core   +2 more sources