Results 61 to 70 of about 286,880 (314)
The 5 ' untranslated region of protein kinase C delta directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis. [PDF]
, 2002 Protein kinase Cdelta (PKCdelta) is a member of the PKC family of phospholipid-dependent serine/threonine kinases and is involved in cell proliferation, apoptosis, and differentiation.
Morrish, B.C., Rumsby, M.G.
core +2 more sources
American Journal of Human Genetics, 2002 Fabry disease is an inborn error of glycosphingolipid catabolism, resulting from deficient activity of lysosomal alpha-galactosidase A (alpha-Gal A). A rare alternative splicing that introduces a 57-nucleotide (nt) intronic sequence to the alpha-Gal A ...
S. Ishii +4 more
semanticscholar +1 more source
Indian Journal of Paediatric Dermatology, 2020 Fabry's disease is a rare X-linked dermatosis, resulting from alpha-galactosidase deficiency and presents with both cutaneous (angiokeratoma, acral paresthesia, and hypohidrosis) and extracutaneous manifestations (ocular, cardiac, renal, and neurological)
Ishmeet Kaur +3 more
doaj +1 more source
Stimulation of bioprocesses by ultrasound [PDF]
, 2011 Ultrasound (US) has become a ubiquitous technological process in a large variety of scientific disciplines. However, little information exists on the use of ultrasound to enhance biological processes and/or processing and consequently this paper provides
Akunna, Joseph C. +4 more
core +3 more sources
Previously Unidentified Gene Variation Associated with Fabry Disease: The Impact on One Family
Case Reports in Nephrology, 2020 Fabry disease is an X-linked lysosomal storage genetic disorder associated with over 1000 mutations in the alpha-galactosidase-A gene region. We report here a 69-year-old male who underwent a kidney biopsy to evaluate progressive renal failure.
Amaresh R. Vanga +3 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Microengineered Gradient Hydrogels for Mechanobiology
Advanced Healthcare Materials, EarlyView.Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong +4 more
wiley +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
SIGNIFICANCE OF GENOTYPIC ALPHA GALACTOSIDASE A MUTATIONS IN FABRY DISEASE TREATMENT
Acta Medica Medianae, 2020 Fabry disease (FD) is a rare inherited X-linked lysosomal storage disorder caused by a deficiency in alfa-galactosidase A (a-GAL). It is resulting in the accumulation of glycosphingolipids that leads to multiple organ dysfunction and ultimately signs and symptoms of the disease.
Jelena Randjelović +5 more
openaire +1 more source