Results 61 to 70 of about 3,545,087 (293)

Tailoring focal plane component intensities of polarization singular fields in a tight focusing system

open access: yesScientific Reports
The scientific community studies tight focusing of radially and azimuthally-polarized vector beams as it is a versatile solution for many applications.
Sushanta Kumar Pal, Leslie A. Rusch
doaj   +1 more source

Bayesian inversion with {\alpha}-stable priors [PDF]

open access: yes, 2023
We propose to use L\'evy {\alpha}-stable distributions for constructing priors for Bayesian inverse problems. The construction is based on Markov fields with stable-distributed increments. Special cases include the Cauchy and Gaussian distributions, with
Soto, Tomás   +3 more
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Research into Robust Federated Learning Methods Driven by Heterogeneity Awareness

open access: yesApplied Sciences
Federated learning (FL) has emerged as a prominent distributed machine learning paradigm that facilitates collaborative model training across multiple clients while ensuring data privacy.
Junhui Song   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

RCS characterization using the alpha-stable distribution

open access: yesProceedings of the 1996 IEEE National Radar Conference, 2002
The radar backscatter from complex sources, such as ships and ocean waves, can vary rapidly with target aspect or time. The radar cross section (RCS) of such targets is usually described in statistical terms using one of the many statistical models that are available. These models, however, tend to fit less well when the amplitude fluctuations begin to
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Metcalfe's law and log-period power laws in the cryptocurrencies market

open access: yesEconomics: Journal Articles, 2019
In this paper the authors investigate the statistical properties of some cryptocurrencies by using three layers of analysis: alpha-stable distributions, Metcalfe’s law and the bubble behaviour through the LPPL modelling.
Pele Daniel Traian   +1 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Strictly stable distributions on convex cones

open access: yes, 2008
Using the LePage representation, a symmetric alpha-stable random element in Banach space B with alpha from (0,2) can be represented as a sum of points of a Poisson process in B. This point process is union-stable, i.e.
Davydov, T.   +5 more
core   +2 more sources

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