Results 301 to 310 of about 68,100 (329)

Physical and Mechanical Properties of Monomeric Alpha-Synuclein Provide Leads to Molecular Function. [PDF]

J Phys Chem B
Whitcomb KL, Warncke K.
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Higher molecular weight alpha-synuclein oligomers are increased in brain cytosol from dementia with Lewy bodies

Gregersen E, Antorini MR, Reimer L, Zaccagnini L, Selkoe D, Bartels T, Jensen PH.   +6 more
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Knockdown of mitochondrial sirtuin sir-2.2 reduces alpha-synuclein clearance and impairs energy homeostasis in a model of ageing.

Dis Model Mech
Naseer A, Toppo P, Akbar M, Nazir A.
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Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies

Serdiuk T, Redeker V, Savistchenko J, Neupane S, Haenseler W, Fleischmann Y, Reber V, Keller S, Tiberi C, Bachmann-Gagescu R, Gstaiger M, Braun T, Riek R, Gentleman S, Aguzzi A, de Souza N, Melki R, Picotti P.   +17 more
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Alpha-synuclein and Parkinson's disease

Cellular and Molecular Life Sciences, 2000
The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different alpha-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's disease (PD), but only in a small number of ...
C B, Lücking, A, Brice
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Prion Properties of Alpha-Synuclein

Molecular Biology, 2019
The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and its various conformers are discussed.
A L, Schwarzman, K A, Senkevich, A K, Emelyanov, S N, Pchelina   +3 more
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Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity

Molecular Biology Reports, 2009
Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over ...
Xu, Liangliang, Hou, Yonghui, E, Shunmei, Gong, Shoufang, Zhou, Wei, Zou, Jiangying   +5 more
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Alpha-synuclein and Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004
Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in alpha-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of alpha-
RECCHIA, ALESSANDRA, DEBETTO, PATRIZIA, NEGRO, ALESSANDRO, GUIDOLIN, DIEGO, SKAPER SD, GIUSTI, PIETRO   +5 more
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