Results 301 to 310 of about 1,144,970 (369)

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau. [PDF]

Protein Sci
Saleh IG, Shimogawa M, Ramirez J, Abakah B, Venkatesh Y, James HP, Li MH, Louie SA, Lougee MG, Chia WK, Brue C, Cooley RB, Mehl RA, Baumgart T, Mach RH, Eliezer D, Rhoades E, Petersson EJ.   +17 more
europepmc   +1 more source

Deep Brain Stimulation in Swallowing Disorders in Individuals With Parkinson's Disease: A Narrative Review

Sensory Neuroscience, EarlyView.
ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non‐motor symptoms, with dysphagia being one of the most frequent and debilitating complications in advanced stages. Deep brain stimulation (DBS), widely used to alleviate motor symptoms in PD, has recently drawn attention for its potential ...
Gizem Büyükönder, Mümüne Merve Parlak   +1 more
wiley   +1 more source

Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits. [PDF]

eNeuro
Kim Y, Vaidya B, McInnes J, Zoghbi HY.
europepmc   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, EarlyView.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Neuromodulation influences T lymphocyte calcium signaling and alpha synuclein clearance: implications for Parkinson's disease. [PDF]

Front Cell Neurosci
Ross A, Prowse N, Zhang H, Hayley S, Sun H.   +4 more
europepmc   +1 more source

Exploring exosome profiling via CytoFLEX Nano flow cytometer: Approaches and applications

VIEW, EarlyView.
This study evaluated CytoFLEX Nano flow cytometer's exosome detection performance, comparing it with traditional CytoFLEX in sensitivity, repeatability, and fluorescence labeling. Notably, the CytoFLEX Nano demonstrates distinct advantages: enhanced sensitivity, improved selectivity, and expanded applicability.
Li Cao, Hui Wang, Jiaqi Zhu, Wen Li, Lin Han, Zhuanzhuan Wang, Xiaofei Wang, Bo Guo, Jiangbo Ding, Dongdong Tong, Chen Huang   +10 more
wiley   +1 more source

Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease‐Like Brain Transcriptomic Signatures in AppNL‐G‐F Mice

Aging Cell, EarlyView.
Choline‐protected genes correlated with clinical dementia rating, inflammation, and tauopathy in human AD samples, suggesting that adequate choline intake could be a preventive strategy for Alzheimer's disease (AD). ABSTRACT Alzheimer's disease (AD)—the leading cause of dementia—has no cure, inadequate treatment options, and a limited understanding of ...
Thomas A. Bellio, Andre Krunic, Mary S. Campion, Rohan Dupaguntla, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +8 more
wiley   +1 more source

Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Otero-Jimenez M, Wojewska MJ, Jogaudaite S, Miller D, Gray-Rodriguez S, Geoghegan GC, Abelleira-Hervas L, Viney TJ, Sarkany B, Gveric D, Gentleman S, Alegre-Abarrategui J.   +11 more
europepmc   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source