Results 311 to 320 of about 1,144,970 (369)

Coronin1A Regulates the Trafficking of Alpha Synuclein in Microglia. [PDF]

J Neurosci
Biggs KE, Fikse EN, Anderson FL, Kettenbach AN, Havrda MC.   +4 more
europepmc   +1 more source

Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform

Brain Pathology, EarlyView.
The Halo microglial activation module has not been formally validated in the literature. Comparison of this module with established methods revealed varied performance dependent on tissue thickness, highlighting the need for care to be taken when optimising image analysis parameters. Abstract Phenotypic changes in microglia have been linked to multiple
Laura M. Carr, Bianca Guglietti, Ing Chee Wee, Ian F. Musgrave, Sanam Mustafa, Frances Corrigan, Lyndsey E. Collins‐Praino   +6 more
wiley   +1 more source

Alpha-synuclein misfolding as fluid biomarker for Parkinson's disease measured with the iRS platform. [PDF]

EMBO Mol Med
Schuler M, Gerwert G, Mann M, Woitzik N, Langenhoff L, Hubert D, Duman D, Höveler A, Galkowski S, Simon J, Denz R, Weber S, Kwon EH, Wanka R, Kötting C, Güldenhaupt J, Beyer L, Tönges L, Mollenhauer B, Gerwert K.   +19 more
europepmc   +1 more source

Hunting the Chameleon: Structural Conformations of the Intrinsically Disordered Protein Alpha‐Synuclein

, 2012
Malte Drescher, Martina Huber, Vinod Subramaniam   +2 more
openalex   +2 more sources

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Correction: The Role of Alpha-Synuclein and Tubulin-Associated Unit (Tau) Proteins in the Diagnosis, Prognosis, and Treatment of Parkinson's Disease: A Systematic Review. [PDF]

Cureus
Lin YM, Banoth D, Wali MH, Bekova K, Abdulla N, Gurugubelli S, Khan S.   +6 more
europepmc   +1 more source

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease [PDF]

, 2018
Bateman, Randall J, Benzinger, Tammie L.S., et al,, Fagan, Anne, Karch, Celeste M, Morris, John C   +5 more
core   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review. [PDF]

Mol Neurodegener
Bregendahl M, Kaya ZB, Singer W, McLean PJ.   +3 more
europepmc   +1 more source

Criterion for Assessing Accumulated Neurotoxicity of Alpha-Synuclein Oligomers in Parkinson's Disease. [PDF]

Int J Numer Method Biomed Eng
Kuznetsov AV.
europepmc   +1 more source