Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Blood Gas Interpretation Under Hypothermic Conditions: A Comparative Study of Alpha-Stat and pH-Stat in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]
Gandhi V +5 more
europepmc +1 more source
Mapping the Extended Lyman-Alpha Emission within the Circumgalactic Medium of Quasars Hosted by Dusty Starbursts with CubeCarve [PDF]
Kevin Hall, Hai Fu
openalex
A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones. [PDF]
Abigail C. Buenafe +5 more
openalex +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Using a self-modulated treadmill as a novel approach to study cognitive-motor and biomechanical outcomes during dual-task walking in individuals with and without lower limb loss. [PDF]
Shaw EP +12 more
europepmc +1 more source

