Results 111 to 120 of about 26,458 (238)

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol‐Associated Cirrhosis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 12, Page 1673-1684, June 2026.
We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo, Sepideh Mehravar, Ellen Choi, Ju Dong Yang, Hyun‐Seok Kim, Yun Wang, Aarshi Vipani, Hirsh D. Trivedi, Walid Ayoub, Parnian Naji, Alexander Kuo, Chun‐Ying Wu, Lorenzo Leggio, Juan Pablo Arab   +13 more
wiley   +1 more source

Late Onset Telomere Biology Disorder Presenting With Pancytopenia, Immune Dysregulation, Interstitial Lung Disease and Alopecia

American Journal of Hematology, Volume 101, Issue 6, Page 1196-1200, June 2026.
Bo A. Wan, Hamish Nicolson, Heather A. Leitch, Ryan J. Stubbins, Luke Y. C. Chen, Timothy Murray, Amy Trottier, Anthony Gador   +7 more
wiley   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan, Jacqueline L. Stair, Daniel Baker, Neil Spooner, Darragh Murnane   +4 more
wiley   +1 more source

Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review

, 2017
Ross G Edgar,1,2 Mitesh Patel,3 Susan Bayliss,4 Diana Crossley,2,5 Elizabeth Sapey,2,5 Alice M Turner4,6 1Therapy Services, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 2Institute of Inflammation and Ageing, University of ...
Edgar RG, Crossley D, Bayliss S, Patel M, Sapey E, Turner AM   +5 more
core  

Characterization of Novel Alpha-1-Antitrypsin Coding Variants in a Mammalian Cellular Model

Advances in genetic screening technologies have considerably accelerated the discovery of rare alpha-1-antitrypsin (AAT) variants. Expression in cellular models is an effective approach to evaluate the pathogenic potential of these new AAT variants ...
Fra, Annamaria, Ben Khlifa, Emna, Denardo, Andrea, Bignotti, Mattia   +3 more
core   +1 more source

Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in US Individuals With Chronic Hepatitis B Virus Infection

Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Hepatitis B surface antigen (HBsAg) loss is associated with improved clinical outcomes in patients with chronic hepatitis B virus (HBV) infection based on studies predominantly in Asian populations. We assessed real‐world associations between HBsAg loss and long‐term clinical outcomes in a diverse US population with chronic HBV infection. This
Myriam Drysdale, Rose Chang, Shuang Wang, Anna Coutinho, Vera Gielen, Theo Man, Rui Song, Mei Sheng Duh, Mandana Khalili, Dickens Theodore   +9 more
wiley   +1 more source

Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide

, 2017
Ignacio Blanco,1 Patricia Bueno,2 Isidro Diego,3 Sergio Pérez-Holanda,4 Beatriz Lara,5 Francisco Casas-Maldonado,6 Cristina Esquinas,7 Marc Miravitlles7,8 1Alpha1-Antitrypsin Deficiency Spanish Registry (REDAAT), Lung Foundation Breathe, Spanish ...
Esquinas C, Diego I, Bueno P, Miravitlles M, Lara B, Casas-Maldonado F, Pérez-Holanda S, Blanco I   +7 more
core  

Alpha-1 antitrypsin deficiency in patients with chronic hepatitis

, 2012
Background/aims: Alpha-1 antitrypsin deficiency causes accumulation of mutant alpha-1 antitrypsin molecules in hepatocytes, and is attributed to severe liver injury even in heterozygous state.
Halis SIMSEK, Asli PINAR, Pinar, ASLI, Tatar, G, Gokhan GEDIKOGLU, Özcebe, O, Hasçelık, G, Gulsen HASCELIK, Gonca TATAR, Alp, ALPASLAN, Yahya BUYUKASIK, Altinbaş, A, Gedıkoğlu, G, Akif ALTINBAS, Osman OZCEBE, Yasemin H. BALABAN, Balaban, YH, Şımşek, H, Alparslan ALP, Büyükaşik, Y   +19 more
core   +1 more source

ABO Incompatible Deceased Donor Liver Transplants in Infants (Age < 1 Year): A Single‐Center Experience

Pediatric Transplantation, Volume 30, Issue 6, June 2026.
The liver transplant waitlist mortality for infants (age < 1 year) is currently the highest among all ages. ABO incompatible (ABOi) liver‐transplantation is one of the strategies to increase transplantation rate in infants and can be safely performed in children less than 1 year of age without plasmapheresis, with excellent long‐term outcomes. ABSTRACT
Heli Bhatt, Sarah Kizilbash, Claudia Cohn, Oyedele Adeyi, Daniel Waller, David M. Vock, Gwenyth Fischer, Joseph Resch, Andrew Adams, Srinath Chinnakotla   +9 more
wiley   +1 more source

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update

, 2017
Ignacio Blanco,1 Patricia Bueno,2 Isidro Diego,3 Sergio Pérez-Holanda,4 Francisco Casas-Maldonado,5 Cristina Esquinas,6 Marc Miravitlles6,7 1Alpha1-Antitrypsin Deficiency Spanish Registry (REDAAT), Fundación Respira, Spanish Society of ...
Esquinas C, Diego I, Bueno P, Miravitlles M, Casas-Maldonado F, Pérez-Holanda S, Blanco I   +6 more
core