Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients. [PDF]
Ali RA +4 more
europepmc +1 more source
Human Alpha-1 Antitrypsin Suppresses Melanoma Growth by Promoting Tumor Differentiation and CD8<sup>+</sup> T-Cell-Mediated Immunity. [PDF]
Yamauchi T +8 more
europepmc +1 more source
Prevalence of genetic mutations in Alpha-1 antitrypsin in patients with difficult-to-treat asthma in Colombia. [PDF]
Alí-Munive A +7 more
europepmc +1 more source
Applications of Artificial Intelligence in Alpha-1 Antitrypsin Deficiency: A Systematic Review from a Respiratory Medicine Perspective. [PDF]
Casal-Guisande M +5 more
europepmc +1 more source
Alpha-1 antitrypsin deficiency with the rare IZ phenotype presenting as cystic lung disease. [PDF]
Reed TJ, Shisler R, Collins J.
europepmc +1 more source
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Alpha‐1‐Antitrypsin Deficiency
Clinical Liver Disease, 2022Content available: Author Audio Recording.
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Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency
The American Journal of Medicine, 1988Alpha-1-antitrypsin (A1AT) deficiency is a genetic disorder characterized by low serum levels of A1AT and a high risk for the development of emphysema. A1AT is the principal inhibitor of neutrophil elastase, such that a deficiency of A1AT results in insufficient anti-elastase protection in the lower respiratory tract, thus allowing neutrophil elastase ...
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Alpha-1 Antitrypsin Deficiency
2023Alpha-1 antitrypsin (AAT) deficiency is a common monogenic disorder in which there is a strong founder effect of a single missense mutation in SERPINA1, the gene encoding this major circulating serum anti-protease that is normally expressed primarily in hepatocytes.
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Alpha-1-antitrypsin in malakoplakia
Virchows Archiv A Pathological Anatomy and Histology, 1982Macrophages in malakoplakia contain large amounts of immunoreactive alpha-1-antitrypsin (AAT). The amount of AAT remains unchanged during the morphogenetic stages of the pathological process (early, granulomatous, fibrosing phases), and does not correlate with the number or the presence of Michaelis-Gutmann (M.G.) bodies.
F, Callea, B, Van Damme, V J, Desmet
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