Results 251 to 260 of about 1,649,512 (376)

Impact of Alpha Interferon and Ribavirin on the Function of Maturing Dendritic Cells

, 2004
Eleanor Barnes, Mariolina Salio, Vincenzo Cerundolo, Joanne Medlin, Shona Murphy, Geoffrey Dusheiko, Paul Klenerman   +6 more
openalex   +1 more source

Presence of an acid-labile alpha-interferon in sera from fetuses and children with congenital rubella

Journal of Clinical Microbiology, 1985
P. Lebon, F. Daffos, A. Checoury, L. Grangeot‐Keros, F. Forestier, J. Toublanc   +5 more
semanticscholar   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

A case of chronic myelogenous leukemia with hemolytic uremic syndrome similar renal lesions during long- term interferon - .ALPHA. therapy.

, 1997
H. Kobayashi, Yasunori Utsunomiya, Yasushi Miyazaki, Goro Tokutome, Tetsuya Kawamura, T Hashimoto, Tomoko Sakai, Shinʼichi Takahashi, A. Tojyo, Shigetaka Asano   +9 more
openalex   +2 more sources

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

The impact of JAK2^V617F variant allele frequency in MPN patients following PEGylated interferon alpha discontinuation. [PDF]

Br J Haematol
Brown R, Bennett R, Crean C, Hindley A, McGimpsey J, Cunningham N, Niblock A, McPherson S, Boyd K, Foy A, Graham C, Greenfield G, McMullin MF, Catherwood MA.   +13 more
europepmc   +1 more source

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript.

, 1993
Chenhui Wang, Stefan N. Constantinescu, David J. MacEwan, Berta Strulovici, Lodewijk V. Dekker, Peter J. Parker, Lawrence M. Pfeffer   +6 more
openalex   +2 more sources

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Markers of Antiviral Response in SLE Patients After Vaccination Against SARS-CoV-2. [PDF]

Int J Mol Sci
Komorniczak M, Lisowska KA, Bułło-Piontecka B, Dębska-Ślizień A, Wardowska A.   +4 more
europepmc   +1 more source