Results 261 to 270 of about 1,649,512 (376)

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Different Biological Activities of Specific Interferon Alpha Subtypes

mSphere, 2019
Kim J. Hasenkrug, Kerry J. Lavender, Mario L. Santiago, Kathrin Sutter, Ulf Dittmer   +4 more
doaj   +1 more source

Evaluating the feasibility of a network meta-analysis comparing treatment options in polycythemia vera. [PDF]

J Comp Eff Res
Walden P, Hummel N, Kopiec A, Maliszewska Z, Naslazi E.   +4 more
europepmc   +1 more source

Comparision Of The Side Effects Due To Interferon Alpha 2a Plus Ribavirin And Pegylated Interferon Alpha 2a Plus Ribavirin Combinations For Chronic Hepatitis C Infection

, 2009
Onur Ural, Nazlım Aktuğ Demir, Şua Sümer, Gaye Ural, Mehmet Balcı   +4 more
openalex   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, EarlyView.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Alcohol dependence-induced astrocyte immune activation in the nucleus accumbens. [PDF]

Neurobiol Dis
Hashimoto JG, Mangieri RA, Roberts AJ, Lime T, Davis BA, Carbone L, Roberto M, Guizzetti M.   +7 more
europepmc   +1 more source

2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.

, 1989
H. Bielefeldt Ohmann, Marli Matiko Anraku de Campos, Philip Griebel, Lorne A. Babiuk   +3 more
openalex   +1 more source

A FATAL CASE OF BILATERAL INTERSTITIAL PNEUMONIA (BLIP): INTERFERON ALPHA 2 A INDUCED.

, 2017
Balaji Ommurugan, Laxminarayana Kurady Bairy, Amita Priya, Joseph Thomas, Navin Patil   +4 more
openalex   +2 more sources

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Advanced Science, EarlyView.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang, Wenfang Zhang, Jiyang Zhang, Chenhui Zhao, Wei Zhang, Menghan Fang, Fangfang Chen, Zhida Wu, Xiaoya Xu, Ziqing Yu, Qiong Zhu, Yi Shi, Dadong Zhang, Xiaofeng Chen, Gang Chen   +14 more
wiley   +1 more source

Behçet's disease unraveled: Insights into clinical manifestations, diagnosis, and management. [PDF]

Medicine (Baltimore)
Alghamdi M, Lindsey S.
europepmc   +1 more source