Results 271 to 280 of about 362,526 (330)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

The effect of diquafosol on tear film inflammatory markers in patients with dry eye: A noncomparative, open-label, proof-of-concept study. [PDF]

J Int Med Res
Tanchuling RV, Tan PVC, Regalado RNC, Lim Bon Siong R.   +3 more
europepmc   +1 more source

Excision of interferon beta-1b-associated plate-like secondary osteoma cutis. [PDF]

JAAD Case Rep
Sandoval K, Carey D.
europepmc   +1 more source

Case Report: When an unknown fever unmasks Erdheim-Chester disease: a case showing the use of multimodality imaging and the successful interferon alpha therapy. [PDF]

F1000Res
Boudriga H, Ben Hassine I, Ben Elkilani O, Sfar R, Ezzine A, Anoun J, Mzabi A, Ben Fredj F, Chatti K.   +8 more
europepmc   +1 more source

Table S1 from Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death that Combines with Interferon Alpha Therapy for Tumor Control

Jordan A. Stinson, Allison Sheen, Brianna M. Lax, Grace N. Yang, Lauren Duhamel, Luciano Santollani, Elizabeth Fink, Joseph R. Palmeri, K. Dane Wittrup   +8 more
openalex   +1 more source

Interferon-stimulated Viperin impairs Treg function in autoimmune thrombocytopenia. [PDF]

Cell Commun Signal
Li T, Li X, Huang H, Liu P, Shen Z, Xue C.   +5 more
europepmc   +1 more source

<i>VILMIR</i> is a <i>trans</i>-acting long noncoding RNA that enhances the host interferon response in human epithelial cells. [PDF]

J Virol
John K, Smith E, Istishin A, Mahmood N, Diveley K, Tollison TS, Carpenter S, Peng X.   +7 more
europepmc   +1 more source

Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants

Somji R, Brown JC, Rowles-Khalid S, Abdullahi T, Luo D, Barthel N, Mülleder M, Ralser M, Barclay WS, Rallis C, Giotis ES.   +10 more
europepmc   +1 more source