Results 301 to 310 of about 1,649,512 (376)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Interferon therapy-induced reduction in PD-1 + CD8 + and CD160 + CD8 + T cells is associated with functional cure in hepatitis B. [PDF]

BMC Infect Dis
Zhou D, Liu J, Jia J, Li H, Qin L, Zhang Z, Cao Z.   +6 more
europepmc   +1 more source

Exhaustion of NK cells and interferon activation in anti-MDA5⁺ dermatomyositis are associated and determine the development of ILD. [PDF]

Front Immunol
Shao C, Zhen Y, Xia N, Zhang X, Yan N, Zhou M, Guo Y, Tan L, Guo Q.   +8 more
europepmc   +1 more source

IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection. [PDF]

J Transl Med
Arca-Lafuente S, Lara-Aguilar V, Llamas-Adán M, Grande-García S, Deza de la Casa A, Martín-Carbonero L, Ryan P, de Los Santos I, Matarranz M, Jiménez-Sousa MÁ, Fernández-Rodríguez A, Briz V.   +11 more
europepmc   +1 more source

Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants

Somji R, Brown JC, Rowles-Khalid S, Abdullahi T, Luo D, Barthel N, Mülleder M, Ralser M, Barclay WS, Rallis C, Giotis ES.   +10 more
europepmc   +1 more source

Beta Interferon 1a and Laquinimod Differentially Affect Coagulation-Related Gene Expression in Multiple Sclerosis Patients: Implications for Clinical Efficacy and Side Effects. [PDF]

Int J Mol Sci
Gurevich M, Zilkha-Falb R, Chapman J, Drori T.   +3 more
europepmc   +1 more source