Results 121 to 130 of about 187,147 (274)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma   +2 more
wiley   +1 more source

Functional Segregation of Epileptogenicity within the Human Amygdala

open access: yesAnnals of Neurology, EarlyView.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys   +14 more
wiley   +1 more source

Periodicity in wide-band time series [PDF]

open access: yes, 2002
Summary: To test the hypotheses that (i) electroencephalograms (EEGs) are largely made up of oscillations at many frequencies and (ii) that the peaks in the power spectra represent oscillations, we applied a new method, called the Period Specific ...
Bullock, T.H.   +2 more
core  

Giant Magnetostriction in Ferrimagnetic SmFe5As3

open access: yesAngewandte Chemie International Edition, EarlyView.
SmFe5As3 is a newly discovered ferrimagnetic material that displays peculiar volumetric effects as a function of temperature. As a result of two magnetic sublattices—one with d$d$‐electrons of Fe and another with f$f$‐electrons of Sm—single crystals of SmFe5As3 show negative (blue), positive (pink), and zero (beige) thermal expansion along the [010 ...
Oksana Karychort   +21 more
wiley   +1 more source

Short‐Term Scheduling Optimization of a Single‐Pipeline Refining System With High Melting Point Crude Oil

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT In order to reflect the actual production situation more comprehensively and optimize the production cost, this paper solves the short‐term scheduling optimization problem for a single pipeline containing high melting point crude oil. Based on the refining plan given by the upper layer, a multi‐objective optimization model with high melting ...
Jing Yao   +5 more
wiley   +1 more source

Osteohistology of two phorusrhacids reveals uninterrupted growth strategy

open access: yesThe Anatomical Record, EarlyView.
Abstract Phorusrhacidae were apex predators that primarily dominated South America ecosystems for at least 40 million years with their imposing size and predatory lifestyle—yet some aspects of their biology remain poorly understood. Osteohistology is a tool for understanding growth dynamics and biomechanical adaptations.
Lotta Dreyer   +2 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

open access: yesAnimal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang   +6 more
wiley   +1 more source

Research on the pathogenesis of Alzheimer's disease based on thalamocortical computational model

open access: yesFrontiers in Neurology
Alpha rhythm slowing is an important electroencephalogram(EEG) feature associated with (AD). This study aims to understand the correlation between alpha band deceleration and molecular changes from the perspective of neural computing.
Yijin Gang   +6 more
doaj   +1 more source

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