Results 31 to 40 of about 207,548 (205)
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Alphabetic order of authors in scholarly publications: a bibliometric study for 27 scientific fields
, 2020 Paper authorship and author placement have significant consequences for accountability and assignment of credit. Moreover, authors in different scientific fields tend to follow distinct approaches towards their ordering in scholarly publications.
Cortez, Paulo, Fernandes, João M.
core +1 more source
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
When Biology Meets Medicine: A Perspective on Foundation Models
Advanced Intelligent Discovery, EarlyView.Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu +3 more
wiley +1 more source
Alphabetic Searching in Videotex Systems [PDF]
, 1981 Of the four major types of interactive videotex systems currently being tested (Telidon, Teletel, Captains, and Prestel-like) only one (Teletel) permits the use of alphabetic key words for searching.
Maurer, H.A., Rauch, W., Sebestyen, I.
core +1 more source
Optimal Ordering and Trade Credit Policy for EOQ Model [PDF]
Trade credit is the most prevailing economic phenomena used by the suppliers for encouraging the retailers to increase their ordering quantity. In this article, an attempt is made to derive a mathematical model to find optimal credit policy and hence ...
Nita H. Shah, Hardik Soni
core
High-resolution x-ray scattering studies of charge ordering in highly correlated electron systems [PDF]
, 2002 Many important properties of transition metal oxides such as, copper oxide high- temperature superconductivity and colossal magnetoresistance (CMR) in manganites are due to strong electron-electron interactions, and hence these systems are called highly ...
Ghazi, Mohammad Ebrahim
core
Alphabetic Scribes in Hellenistic Uruk
, 2021 Professional titles are scarcely used in socurces from Hellenistic Uruk as a means of identification. The fact that individuals bearing the title of alphabetic scribes feature so prominently in the corpus must therefore bear a special significance.
Paola Corò
core +1 more source
Advanced Intelligent Discovery, EarlyView.An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li +9 more
wiley +1 more source