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2010
Alphaviruses remain important emerging mosquito-borne, zoonotic pathogens that cause both localized human outbreaks and epizootics (e.g., Venezuelan equine encephalitis) and large human epidemics (e.g., Chikungunya). Alphaviruses are globally dispersed, and each continent has humans at risk from one or more of these arthropod-borne viruses (arboviruses)
A M, Powers, John T, Roehrig
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Alphaviruses remain important emerging mosquito-borne, zoonotic pathogens that cause both localized human outbreaks and epizootics (e.g., Venezuelan equine encephalitis) and large human epidemics (e.g., Chikungunya). Alphaviruses are globally dispersed, and each continent has humans at risk from one or more of these arthropod-borne viruses (arboviruses)
A M, Powers, John T, Roehrig
+6 more sources
International Reviews of Immunology, 2004
Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Trends in Microbiology, 1995
The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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Virus Research, 2004
Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik, Garoff +2 more
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Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik, Garoff +2 more
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Opsonization of alphaviruses in hamsters
Journal of Medical Virology, 1983AbstractImmune elimination of alphaviruses in immunized hamsters appears to involve formation of virus/antibody aggregates which are subsequently cleared from the circulation by cells of the reticuloendothelial system (RES). Virulent strains of Venezuelan (VEE) and Western equine encephalitis (WEE) viruses which were cleared slowly from the circulation
P B, Jahrling +3 more
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Studies on the morphology of alphaviruses
Virology, 1979Abstract The symmetrical arrangement of subunits in envelope and nucleocapsid of alphaviruses (Sindbis and Semliki Forest) was investigated. The 80 subunits of the envelope display a hexon-penton clustering in a T = 4 icosahedral surface lattice. The glycoprotein projections are located in bundles on the surface of the morphological subunits.
P J, Enzmann, F, Weiland
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Tropical Arthritogenic Alphaviruses
Reumatología Clínica (English Edition), 2018Tropical alphaviruses have special tropism for bone and joint tissue. Patients can develop chronic rheumatic disorders similar to rheumatoid arthritis and ankylosing spondylitis. The prototype is Chikungunya virus, although other lesser known viruses in our environment such as Sindbis, Ross River, Mayaro, O'nyong nyong and Barmah Forest viruses have ...
Carla-Ruth, Mejía +1 more
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Arthritogenic alphaviruses—an overview
Nature Reviews Rheumatology, 2012Mosquito-transmitted alphaviruses causing human rheumatic disease are globally distributed and include chikungunya virus, Ross River virus, Barmah Forest virus, Sindbis virus, o'nyong-nyong virus and Mayaro virus. These viruses cause endemic disease and, occasionally, large epidemics; for instance, the ...
Andreas, Suhrbier +2 more
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Infection of Cells by Alphaviruses
2011It is widely accepted that alphaviruses enter cells by a process involving endocytosis and low-pH-mediated virus membrane-cell membrane fusion. This model and the data supporting it have received extensive and numerous reviews. The major points presented in support of this model are summarized briefly herein.
Dennis T, Brown, Raquel, Hernandez
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Structure and Assembly of Alphaviruses
1982The alphaviruses are enveloped animal viruses that belong to the family of Toga viruses. The molecular biology of this virus group is almost entirely based on studies with two members of this virus group, the Semliki Forest Virus (SFV) and the Sindbis virus.
H, Garoff, C, Kondor-Koch, H, Riedel
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