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Alphaviruses as expression vectors
Current Opinion in Biotechnology, 1997Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology ...
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Alphaviruses in cancer immunotherapy
2023Alphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells.
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Future Virology, 2011
Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading
Foo, Suan Sin +7 more
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Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading
Foo, Suan Sin +7 more
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Vaccine elicitation and structural basis for antibody protection against alphaviruses
Cell, 2023Matthew S. Sutton +31 more
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Alphaviruses as vectors for gene delivery
Trends in Biotechnology, 1996Alphavirus vectors have become an important complement to the systems available for transient expression of cloned sequences in cell culture and in vivo. They express foreign sequences from cytoplasmically self-replicating RNA, which can be delivered into the cell either as RNA or DNA.
P, Berglund +2 more
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Molecular Medicine Today, 1999
The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
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The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
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Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates.
Journal of General Virology, 2021Israel Guerrero-Arguero +5 more
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