Results 1 to 10 of about 371,257 (337)

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Nature Communications, 2022
CD28 costimulatory signalling can be suppressed by immune checkpoints, such as CTLA-4 and PD-1. Here the authors describe the design of the fusion therapeutic davoceticept (ALPN-202), based on a variant CD80 extracellular domain engineered to bind PD-L1 ...
Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng   +19 more
doaj   +1 more source

Habitat, Snow-Cover and Soil pH, Affect the Distribution and Diversity of Mortierellaceae Species and Their Associations to Bacteria

Frontiers in Microbiology, 2021
Mortierellaceae species are among the most frequent and globally distributed soil fungi. However, the factors shaping their diversity and distribution remain obscure.
Anusha Telagathoti, Maraike Probst, Ursula Peintner   +2 more
doaj   +1 more source

Simulations reveal climate and legacy effects underlying regional beta diversity in alpine vegetation

Frontiers in Ecology and Evolution, 2023
IntroductionWhether the distribution and assembly of plant species are adapted to current climates or legacy effects poses a problem for their conservation during ongoing climate change.
George P. Malanson, Elizabeth R. Pansing, Riccardo Testolin, Riccardo Testolin, Borja Jiménez-Alfaro   +4 more
doaj   +1 more source

Functional and Structural Responses of Arctic and Alpine Soil Prokaryotic and Fungal Communities Under Freeze-Thaw Cycles of Different Frequencies

Frontiers in Microbiology, 2020
Ongoing climate change involves increasing snow scarcity, which results in more frequent freeze-thaw cycles (FTCs) in polar and alpine soils. Although repeated FTCs have been shown to alter the structure and functions of soil microbial communities, a ...
Carla Perez-Mon, Beat Frey, Aline Frossard   +2 more
doaj   +1 more source

Not Too Warm, Not Too Cold: Thermal Treatments to Slightly Warmer or Colder Conditions from Mother’s Origin Can Enhance Performance of Montane Butterfly Larvae

Biology, 2022
Climate change alters organismal performance via shifts in temperature. However, we know little about the relative fitness impacts of climate variability and how cold-adapted ectotherms mediate these effects.
Konstantina Zografou, George C. Adamidis, Brent J. Sewall, Andrea Grill   +3 more
doaj   +1 more source

Tibial Plateau Fractures among Alpine Skiers: A Retrospective Case Series

Osteology, 2023
The purpose of this retrospective case series was to review the demographics of alpine skiers who sustain tibial plateau fractures, evaluate the inter-observer reliability of the Schatzker classification for fractures sustained while alpine skiing, and ...
Tyler R. Williamson, Joel N. Smith, Britta L. Swanson, John D. Robinson, Keith R. Swanson, Kyle E. Swanson   +5 more
doaj   +1 more source

Shrub growth in the Alps diverges from air temperature since the 1990s

Environmental Research Letters, 2021
In the European Alps, air temperature has increased almost twice as much as the global average over the last century and, as a corollary, snow cover duration has decreased substantially.
Loïc Francon, Christophe Corona, Irène Till-Bottraud, Philippe Choler, Erwan Roussel, Bradley Z Carlson, Samuel Morin, Brigitte Girard, Markus Stoffel   +8 more
doaj   +1 more source

Plant Responses to Changing Water Supply and Availability in High Elevation Ecosystems: A Quantitative Systematic Review and Meta-Analysis

Land, 2021
Climate change is expected to lead to changes to the amount, frequency, intensity, and timing of precipitation and subsequent water supply and its availability to plants in mountain regions worldwide.
Emma Sumner, Susanna Venn
doaj   +1 more source

A new species of Bidessus from Anjozorobe-Angavo and a review of Malagasy Bidessus (Coleoptera, Dytiscidae)

European Journal of Taxonomy, 2020
We review the species of Bidessus of Madagascar and describe Bidessus anjozorobe sp. nov. from material collected in Anjozorobe forest. Anjozorobe is part of the Anjozorobe-Angavo Protected Area, which is an important corridor of transition forest ...
Johannes Bergsten, Tolotra Ranarilalatiana, Olof Biström   +2 more
doaj   +1 more source

Functional traits of alpine plant communities show long‐term resistance to changing herbivore densities

Ecosphere, 2021
Herbivores shape vegetation by suppressing certain plant species while benefitting others. By thus modifying plant species functional composition, herbivores affect carbon cycling, albedo, vegetation structure and species' interactions.
Katariina E. M. Vuorinen, Gunnar Austrheim, Atle Mysterud, Ragnhild Gya, Vigdis Vandvik, John‐Arvid Grytnes, James D. M. Speed   +6 more
doaj   +1 more source