Results 41 to 50 of about 13,848 (209)

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]

, 2020
Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A, Hum, Nicholas R, Loots, Gabriela G, McCool, Jillian L, Mendez, Melanie E, Murugesh, Deepa K, Rios-Arce, Naiomy D, Sebastian, Aimy   +7 more
core   +2 more sources

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts [PDF]

, 2019
© 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries.
Arnett, Timothy R, Bourne, Lucie E, Davies, Bethan K, MacRae, Vicky E, Orriss, Isabel R, Patel, Jessal, Wheeler-Jones, Caroline P D   +6 more
core   +5 more sources

THU459 Hypophosphatasia With Normal ALPL Gene Test; A Case Report

Journal of the Endocrine Society, 2023
Abstract Disclosure: K. Alkwatli: None. L.Z. Khan: None. Introduction: Hypophosphatasia is a rare hereditary disorder caused by loss of tissue nonspecific alkaline phosphatase activity, an essential enzyme in phosphate metabolism. Severe cases present perinatally and in early childhood.
Alkwatli, Kenda, Khan, Leila Zeinab
openaire   +1 more source

Bioactive sphene-based ceramic coatings on cpTi substrates for dental implants: An in vitro study [PDF]

, 2018
Titanium implant surface modifications have been widely investigated to favor the process of osseointegration. The present work aimed to evaluate the effect of sphene (CaTiSiO5) biocoating, on titanium substrates, on the in vitro osteogenic ...
Badocco, Denis, Biasetto, Lisa, Brunello, Giulia, Elsayed, Hamada, Ferroni, Letizia, Gardin, Chiara, Pastore, Paolo, Sivolella, Stefano, Zavan, Barbara   +8 more
core   +2 more sources

Establishment of a new human iPSC cell line (UOMi007-A) from a patient with Hypophosphatasia

Stem Cell Research, 2022
Hypophosphatasia (HPP) is a rare, inherited, metabolic, genetic disorder, which arises due to loss of function mutation in the alkaline phosphatase (ALPL) gene.
Abhay Srivastava, Rishma Jaryal, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +3 more
doaj   +1 more source

Novel ALPL genetic alteration associated with an odontohypophosphatasia phenotype

Bone, 2013
Hypophosphatasia (HPP) is an inherited disorder of mineral metabolism caused by mutations in ALPL, encoding tissue non-specific alkaline phosphatase (TNAP). Here, we report the molecular findings from monozygotic twins, clinically diagnosed with tooth-specific odontohypophosphatasia (odonto-HPP). Sequencing of ALPL identified two genetic alterations in
Martins, Luciane, Rodrigues, Thaisângela L., Ribeiro, Mariana Martins, Saito, Miki Taketomi, Giorgetti, Ana Paula Oliveira, Casati, Márcio Z., Sallum, Enilson A., Foster, Brian L., Somerman, Martha J., Nociti, Francisco H.   +9 more
openaire   +2 more sources

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations

Bone, 2021
ALPL encodes tissue-nonspecific alkaline phosphatase (TNAP), an enzyme expressed in bone, teeth, liver, and kidney. ALPL loss-of-function mutations cause hypophosphatasia (HPP), an inborn error-of-metabolism that produces skeletal and dental mineralization defects.
K, Kramer, M B, Chavez, A T, Tran, F, Farah, M H, Tan, T N, Kolli, E J Lira, Dos Santos, H F, Wimer, J L, Millán, L J, Suva, D, Gaddy, B L, Foster   +11 more
openaire   +3 more sources

Exact Wavefunctions for a Delta Function Bose Gas with Higher Derivatives [PDF]

, 1996
A quantum mechanical system describing bosons in one space dimension with a kinetic energy of arbitrary order in derivatives and a delta function interaction is studied. Exact wavefunctions for an arbitrary number of particles and order of derivative are
Barcelos-Neto, Barcelos-Neto, Barrow, Bergknoff, Bethe, Dube, Dube, Eric D. Williams, Fradkin, Hamazaki, Korepin, Korepin, Lamb, Lieb, Lieb, Lieb, Lieb, Mijic, Starobinsky, Stelle, Weyl, Weyl, Yang, Yang   +23 more
core   +3 more sources

Analysis of alkaline phosphatase, soluble acid phosphatase, low density lipoprotein and vitamin D binding protein gene polymorphisms as possible gene-candidates participating in mineral bone density determination in women with primary osteoporosis in postmenopause

Научно-практическая ревматология, 2004
Objective. To investigate the distribution of alkaline phosphatase (ALPL), acid phosphatase I (ACPI), receptor lipoprotein low density (LDLR) and vitamin D binding protein (GC) genotypes in osteoporotic ana nonosteoporotic postmenopausal women and the ...
M Y Krylov, V A Myakotkin, L L Benevolenskaya   +2 more
doaj   +1 more source

A novel de novo heterozygous ALPL nonsense mutation associated with adult hypophosphatasia [PDF]

Osteoporosis International, 2020
Using genetic, clinical, biochemical, and radiographic assessment and bioinformatic approaches, we present an unusual case of adult HPP caused by a novel de novo heterozygous nonsense mutation in the alkaline phosphatase (ALPL).Hypophosphatasia (HPP) is caused by genetic alterations of the ALPL gene, encoding the tissue-nonspecific isozyme of alkaline ...
L. Martins, E.L. dos Santos, A.B. de Almeida, R.A. Machado, A.M. Lyrio, B.L. Foster, K.R. Kantovitz, R.D. Coletta, F.H. Nociti   +8 more
openaire   +2 more sources