Results 121 to 130 of about 10,706 (212)

Study on the Potential Molecular Mechanisms of Sodium Dehydroacetate (Na‐DHA) Interfering With Bone Metabolism and Inducing Osteoporosis Based on Network Toxicology, Molecular Docking, and In Vitro Experimental Validation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
The main workflow and core design concept of the current study. ABSTRACT Sodium Dehydroacetate (Na‐DHA), a widely used food additive, has raised concerns about the chronic health risks associated with long‐term exposure. However, the potential impact of Na‐DHA on bone metabolism, its contribution to osteoporosis risk, and the specific molecular ...
Weihong Qian, Qingqing Bao, Xiaoqing Tang, Wuchao Lu, Jiaxin Huang, Jiapeng Bao, Zhihong Yao   +6 more
wiley   +1 more source

AScrFI polymorphism in the human ALPL gene [PDF]

Nucleic Acids Research, 1991
T, Okuyama, N, Matsuo, J, Kudoh, N, Shimizu   +3 more
openaire   +2 more sources

High Prevalence of Nephrocalcinosis in Hypophosphatasia Patients with the ALPL c.1559del Gene Variant

JMA Journal
Hypophosphatasia has been reported to develop nephrocalcinosis, renal stone, and chronic kidney failure. We investigated their renal impairments in the adults with hypophosphatasia to know the phenotype-genotype correlation.We subjected 11 patients with hypophosphatasia who were diagnosed by chance in the routine medical health checkup.
Kawashima, Hisashi, Sasame, Atsuko, Ogaki, Yoko, Nakayama, Takayuki   +3 more
openaire   +2 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, Volume 268, Issue 3, Page 263-275, March 2026.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source

SUN-754 Unveiling a Rare Case of Pediatric Hypophosphatasia: Discovery of a Novel ALPL Gene Variant [PDF]

J Endocr Soc
Abstract Disclosure: M.I. Chiamolera: Consultant of Fleury Group. G.M. Spolador: Fleury Group. J.V. Lima: Consultant of Fleury Group. P. Saddi-Rosa: Fleury Group. R.M. Biscolla: Consultant of Fleury Group. S.S. Maeda: None. Background: Hypophosphatasia (HPP) is a rare disorder caused by variants in the ALPL gene ...
Chiamolera, Maria Izabel, Spolador, Gustavo M, Lima, Jose Viana, Saddi-Rosa, Pedro, Mello Biscolla, Rosa Paula, Maeda, Sergio Setsuo   +5 more
europepmc   +3 more sources

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis [PDF]

, 2014
Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches.
Akker, E.B. (Erik) van den, Bomer, N. (Nils), Bos, S.D. (Steffan), Breggen, R. (Ruud) van der, Darvishan, A. (Arash), Duijnisveld, B.J. (Bouke), Eeden, A.E. (Annelies) van, Heijmans, B.T. (Bastiaan), Hollander, W. (Wouter) den, Lakenberg, N. (Nico), Meulenbelt, I. (Ingrid), Nelissen, R.G.H.H. (Rob), Osch, G.J.V.M. (Gerjo) van, Pepers, B.A. (Barry), Ramos, Y.F.M. (Yolande), Roon-Mom, W.M.C. (Willeke) van, Slagboom, P.E. (Eline), Tobi, E.W. (Elmar), Verbeek, F.J. (Fons)   +18 more
core   +1 more source

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

Hypophosphatasia in childhood: Diagnosis to management

Osteoporosis and Sarcopenia
Hypophosphatasia (HPP) is a rare inherited metabolic bone disorder caused by loss-of-function mutations in the ALPL gene, leading to deficient activity of tissue-nonspecific alkaline phosphatase (TNSALP).
Minji Im, Sung Yoon Cho
doaj   +1 more source

Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles

BMC Medical Genetics, 2009
Background Mild hypophosphatasia (HPP) phenotype may result from ALPL gene mutations exhibiting residual alkaline phosphatase activity or from severe heterozygous mutations exhibiting a dominant negative effect.
Fauvert Delphine, Brun-Heath Isabelle, Lia-Baldini Anne-Sophie, Bellazi Linda, Taillandier Agnès, Serre Jean-Louis, de Mazancourt Philippe, Mornet Etienne   +7 more
doaj   +1 more source