Results 121 to 130 of about 10,834 (202)

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, Volume 36, Issue 31, 16 April 2026.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Plasma Rich in Growth Factors in Bone Regeneration: The Proximity to the Clot as a Differential Factor in Osteoblast Cell Behaviour

Dentistry Journal
The osteogenic differentiation process, by which bone marrow mesenchymal stem cells and osteoprogenitors transform into osteoblasts, is regulated by several growth factors, cytokines, and hormones.
Eduardo Anitua, Mar Zalduendo, Roberto Tierno, Mohammad Hamdan Alkhraisat   +3 more
doaj   +1 more source

3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration [PDF]

, 2015
We acknowledge funding from the QMUL Pump-Priming Research Funding for Cross-Faculty Initiatives 2011-12 ...
Akman, Anselme, Arinstein, Asa H. Barber, Bailey, Boland, Buczynska, Bushby, Chen, De Winter, Earl, Filipe Veiga Almeida, Friedmann, García-Gareta, Gomez-Sanchez, Gupta, Hakimi, Hughes-Brittain, Kim, Kiselev, Kommareddy, Kumbar, Lee, Li, Li, Liu, Martinez, Mattila, Megelski, Michael Cattell, Murphy, Ngiam, Podporska-Carroll, Ramakrishna, Rawlinson, Rumpler, Rutledge, Simon C.F. Rawlinson, Simonet, Smith, Stachewicz, Stachewicz, Stevens, Sun, Trappmann, Truong, Truong, Tuya Qiao, Tzezana, Urszula Stachewicz, Vaquette, Wang, Wei-Qi Li, Wilson, Xie, Xie, Xin, Xue, Zietara   +58 more
core   +3 more sources

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

AScrFI polymorphism in the human ALPL gene [PDF]

Nucleic Acids Research, 1991
T, Okuyama, N, Matsuo, J, Kudoh, N, Shimizu   +3 more
openaire   +2 more sources

High Prevalence of Nephrocalcinosis in Hypophosphatasia Patients with the ALPL c.1559del Gene Variant

JMA Journal
Hypophosphatasia has been reported to develop nephrocalcinosis, renal stone, and chronic kidney failure. We investigated their renal impairments in the adults with hypophosphatasia to know the phenotype-genotype correlation.We subjected 11 patients with hypophosphatasia who were diagnosed by chance in the routine medical health checkup.
Kawashima, Hisashi, Sasame, Atsuko, Ogaki, Yoko, Nakayama, Takayuki   +3 more
openaire   +2 more sources

Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investigated how high glucose levels influence BMSC differentiation, proliferation, viability, and metabolism ...
Suzanna Shirazi, Ezaldeen Esawi, Zeyad D. Nassar, Stan Gronthos, Dimitrios Cakouros   +4 more
wiley   +1 more source

Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling [PDF]

, 2018
Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration.
Aquino Martínez, Rubén Francisco, Artigas, Natalia, Gamez Molina, Beatriz, Rosa López, José Luis, Ventura Pujol, Francesc   +4 more
core   +1 more source

Application of Intracellular Vesicles Surpass Extracellular Vesicles in Regenerative Repair of Inflammatory Bone Defects via the LAMA4‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Periodontitis‐induced inflammatory microenvironment compromises the function of periodontal ligament stem cells (PDLSCs) and significantly impedes the regeneration of periodontal tissues. Meanwhile, the clinical application of extracellular vesicles (EVs) is constrained by their low yield and high production costs.
Haotian Liu, Yu Wu, Qunyi Wang, Ting Zhang, Xin Tong, Fuhua Yan, Qian Zhang   +6 more
wiley   +1 more source

RGD-conjugated rod-like viral nanoparticles on 2D scaffold improve bone differentiation of mesenchymal stem cells [PDF]

, 2014
Viral nanoparticles have uniform and well-defined nano-structures and can be produced in large quantities. Several plant viral nanoparticles have been tested in biomedical applications due to the lack of mammalian cell infectivity.
Huong Giang Nguyen, Kai Li, L. Andrew Lee, Pongkwan Sitasuwan, Qian Wang   +4 more
core   +1 more source