Results 41 to 50 of about 3,793 (179)

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 10, Page 1725-1737, October 2025.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Late Diagnosis of Systemic Scleroderma with Vascular Events: Clinical Case

Вопросы современной педиатрии
Background. Timely diagnosis of systemic scleroderma (SS) can reduce the risk of complications and disability in patients. However, correct diagnosis is complicated by the diversity of disease clinical forms and variants. Clinical case description. SS in
Julia S. Bogomolova, Galina V. Santalova
doaj   +1 more source

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches

Endocrinology, Diabetes &Metabolism, Volume 8, Issue 5, September 2025.
Interplay between erectile dysfunction, diabetes mellitus and genetics. ABSTRACT Introduction Erectile dysfunction (ED) is a highly prevalent complication of diabetes mellitus (DM), significantly impairing quality of life and psychosocial well‐being. The prevalence of ED is estimated to be over 3.5 times higher in men with diabetes mellitus compared to
Boštjan Hostnik, Gašper Tonin, Andrej Janež, Jasna Klen   +3 more
wiley   +1 more source

Clinical efficacy of alprostadil combined with α-lipoic acid in the treatment of elderly patients with diabetic nephropathy

Open Medicine, 2017
To evaluate the effect and toxicity of alprostadil combined with thioctic acid injection in the treatment of patients with diabetic nephropathy (DN).
Hong Yan, Peng Jianyun, Cai Xiaoping, Zhang Xiaoru, Liao Yifei, Lan Lejian   +5 more
doaj   +1 more source

Risk Factors for Serious Hypotension Induced by Intravenous Acetaminophen in Patients With Hematologic Malignancy

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 9, September 2025.
ABSTRACT Purpose Owing to their rapid antipyretic effects and predictable pharmacokinetic properties, acetaminophen (AAP) are commonly administered intravenously to severely ill patients. However, the potential development of hypotension as a consequence of intravenous AAP administration has not been thoroughly addressed.
Yu‐Ri Choi, Ji‐In Park, Seong‐Sim An, Ji‐Hye Choi, Mi‐Na Min, Jin‐Suk Kang, Jee‐Eun Chung   +6 more
wiley   +1 more source

Correction of Kidney Blood Circulation in Patients with Purulent Pyelonephritis

Креативная хирургия и онкология, 2019
Aim. This paper aims to examine the state of the renal blood circulation in patients with purulent pyelonephritis and to improve the quality of treatment through the use of our own technique.Materials and methods.
V. A. Ananev, V. G. Lubyansky, A. V. Antonov   +2 more
doaj   +1 more source

Magnetic resonance imaging‐guided transurethral ultrasound ablation for benign prostatic obstruction: 1‐year clinical outcomes of a phase II study

BJU International, Volume 136, Issue 3, Page 473-483, September 2025.
Objectives To evaluate the safety and efficacy of magnetic resonance imaging (MRI)‐guided transurethral ultrasound ablation (TULSA) as a minimally invasive alternative for benign prostatic obstruction (BPO). Patients and Methods This prospective, single‐centre, early phase II study (NCT03350529) included 30 men with BPO scheduled for primary ...
Antti Viitala, Mikael Anttinen, Pietari Mäkelä, Heikki Pärssinen, Pertti Nurminen, Teija Sainio, Jani Saunavaara, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström   +9 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

European Academy of Neurology (EAN)/European Federation of Autonomic Societies (EFAS)/International Neuro‐Urology Society (INUS) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (NEUROGED Guidelines)

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background Urinary and sexual symptoms are common following neurological disease, and we aimed to develop multidisciplinary inter‐society evidence‐based management guidelines. Methods The ADAPTE framework was used, and a systematic search of guidelines published in different languages was performed.
Jalesh N. Panicker, Alessandra Fanciulli, Magdalena Krbot Skoric, Tamara Kaplan, Katina Aleksovska, Ivan Adamec, Marcio Augusto Averbeck, Nicole Campese, Pietro Guaraldi, Fabian Leys, Jorge Moreno‐Palacios, Sara Simeoni, Iva Stankovic, Sarah Wright, Amit Batla, Bertil Blok, Claire Hentzen, Max Josef Hilz, Thomas M. Kessler, Helmut Madersbacher, Kannan Rajasekharan Nair, Krishnan Padmakumari Sivaraman Nair, Mahreen Pakzad, Anne Pavy‐Le Traon, Guy Peryer, Mikolaj Przydacz, Ryuji Sakakibara, Udit Saraf, Matthew Smith, Walter Struhal, Roland D. Thijs, Katarina Ivana Tudor, Marcin Tutaj, David B. Vodušek, Gregor Wenning, Mario Habek   +35 more
wiley   +1 more source