Results 121 to 130 of about 351,811 (290)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Investigating Clinical Factors Influencing Pulmonary Fibrosis in Acute Diquat Poisoning

International Journal of General Medicine
Meili Xu,1,2 Hongliu Chen,1,2 Jianjing Chen,3 Rongzong Ye,4 Huan Xiao,1,2 Jingwen Li,4 Chaoqian Li1,2 1Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Guangxi University
Xu M, Chen H, Chen J, Ye R, Xiao H, Li J, Li C   +6 more
doaj  

An Old Order (Tobe) Account of the Schisms of Sam Yoder, Abe Troyer-Jake Stutzman, Tobe Hostetler, Joe L. Schwartz, and Seymour, Missouri: An English Translation of <em>Eine Untersuchung in die Alt Amische Gemein von 1922 Bis zu 1974</em> [<em>An Examination in the Old Amish Brotherhood from 1922 to 1974</em>]

, 2019
Gregory Sheets, Dan Raber, Cory Anderson
openalex   +1 more source

FIKIHTA MEZHEP ÇALIŞMALARINI MÜSTAKİL BİR ALT DİSİPLİNE DÖNÜŞTÜRMENİN İMKÂNI: YENİ BİR PERSPEKTİF

, 2022
Bünyamin KORUCU
openalex   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]

Asia Pac J Clin Nutr
Song S, Du H, Lu X, Luo B, Li Z.
europepmc   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Evaluación de los criterios de Centor para el manejo de la faringoamigdalitis en adultos atendidos en el servicio de urgencias

Atención Primaria
Mariona Serrano-Bilbeny, César Gálvez-Barrón, Carlos Pérez-López, Alejandro Rodríguez-Molinero   +3 more
doaj   +1 more source

Neural Heterogeneity Underlying Behavioral Equivalence: A Dynamic Neuro-Decoding Study of Cognitive and Affective Empathy in Relation to Autism-Like Traits. [PDF]

Brain Behav
Zhao L, Jiang Y, Chen Z, Song Y.
europepmc   +1 more source