Results 51 to 60 of about 2,144 (261)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Introduction: Trying to Define Literature’s Confluences
Études Britanniques Contemporaines, 2017 Previous issues of Études britanniques contemporaines chose to focus on the agonistic dynamics of British literature and the arts. The present issue explores a paradigm which has hitherto received very little critical attention. The notion of ‘confluence’
Catherine Bernard
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Exposures: Humour and Vulnerability in some Contemporary British Novels
Études Britanniques Contemporaines, 2016 Some of the most hilarious novels of the last decades begin in gravitas or generate moments of high punctum. This article investigates the ways in which, in contemporary texts, a specific use of humour reverses the logics of comic relief to generate an ...
Jean-Michel Ganteau
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
REPRESENTATIONS OF ALTERITY [PDF]
AnadissLa connaissance du Soi se perfectionne à travers la connaissance de l’Autre. Le Soi se reflète et se reconnaît dans l’Autre, soit par identification, soit par différenciation.
Porfirie PESCARU
doaj
Translating Woolf’s Essays: Reflections on an Experience of Polyvocal Writing
Études Britanniques Contemporaines, 2015 This article focuses on what translating Virginia Woolf’s texts reveals of her writerly practice. It aims at showing how translation is that ‘experience of the other’ Antoine Berman refers to, and above all how it may become a hermeneutic tool unveiling ...
Catherine Bernard
doaj +1 more source