Results 101 to 110 of about 118,709 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Evolutionary Applications, 2022 Abstract Most pathogens are generalists capable of infecting multiple host species or strains. Trade‐offs in performance among different hosts are expected to limit the evolution of generalism. Despite the commonness of generalism, the variation in infectivity, transmission, and trade‐offs in performance among ...
openaire +4 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
The Plant Pathology Journal, 2015 Alternative hosts increase the difficulty of disease management in crops because these alternate hosts provide additional sources of primary inoculum or refuges for diversity in the pathogen gene pool.
Shaukat Ali, M. A. C. Langham
doaj +1 more source
User-space Multipath UDP in Mosh [PDF]
, 2015 In many network topologies, hosts have multiple IP addresses, and may choose among multiple network paths by selecting the source and destination addresses of the packets that they send.
Boutier, Matthieu, Chroboczek, Juliusz
core +3 more sources
ALTERNATIVE HOSTS OF Alternaria cucumerina
, 2009 A mancha ou queima de alternaria em cucurbitáceas é causada pelo fungo Alternaria cucumerina. Esta doença é uma das mais severas em solos arenosos e causa danos devido ao desfolhamento que predispõe os frutos à queimadura do sol, além de redução no tamanho e qualidade dos mesmos.
Batista, Patrício Ferreira +4 more
openaire +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
BIOLOGY, HOST RANGE AND NATURAL ENEMIES OF THE COCONUT SPIDER MITE, Oligonychus velascoi RIMANDO
Annals of Tropical Research, 1987 The total developmental period of the coconut spider mite, Oligonychus velascoi Rimando was 6.3 and 6.9 days for those reared on detached and undetached leaflets, respectively.
Tita L. Cayme, Dely P. Gapasin
doaj
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source