Results 31 to 40 of about 4,460 (211)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pulsed Nanoelectrospray Ionization Boosts Ion Signal in Whole Protein Mass Spectrometry

Applied Sciences, 2021
Electrospray ionisation (ESI) is renowned for its ability to ionise intact proteins for sensitive detection by mass spectrometry (MS). However, the use of a conventional direct current ESI voltage can result in the formation of relatively large initial ...
Qinwen Liu, Ezaz Ahmed, K. M. Mohibul Kabir, Xiaojing Huang, Dan Xiao, John Fletcher, William A. Donald   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Dielectric characteristic of dichlorodifluoromethane (R12) gas and mixture with [inline-formula]/air as an alternative to [inline-formula] gas

High Voltage, 2017
In this study, dichlorodifluoromethane (R12) gas and mixtures with nitrogen (N(2)) and air at different pressures and mixing ratios have been investigated and showed good alternative to [inline-formula] gas in ...
Rahmat Ullah, Abdur Rashid, Arooj Rashid, Faisal Khan, Amjad Ali   +4 more
doaj   +1 more source

Wave processes in alternating current traction network depending on parameters of power supply system [PDF]

Омский научный вестник, 2019
The article considers a mathematical model of the AC traction power supply system taking into account stationary and nonstationary wave processes. The model allows you to analyze the effect of system parameters on electromagnetic processes at its ...
T. V. Kovaleva, O. O. Komyakova, N. V. Pashkova   +2 more
doaj   +1 more source

Electrical Characteristics of Ultra-High-Performance Concrete Containing Carbon-Based Materials

Applied Sciences, 2022
Recently, carbon materials with unique properties, such as high tensile strength and electrical conductivity, have been extensively investigated for the multi-functionalization of concrete.
Kwangmo Lim, Namkon Lee, Gumsung Ryu, Kyungtaek Koh, Kyongchul Kim   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Comparative Analysis of Monitoring Techniques for Polymeric Insulators Under AC and DC Voltage Stresses

IEEE Access
This paper presents a comparative analysis of monitoring techniques applied to polymeric insulators subjected to AC and DC voltages. Electrical tests were conducted on insulators under different operating conditions.
Antonio F. Leite Neto, Pablo B. Vilar, Edson G. Da Costa, Jalberth F. De Araujo, Aylla E. D. Santos, George R. S. Lira, Joao V. J. S. Melo   +6 more
doaj   +1 more source

Leaching of Gold and Copper from Printed Circuit Boards under the Alternating Current Action in Hydrochloric Acid Electrolytes

Metals, 2022
Modern technologies for recycling electronic waste (e-waste) have high economic efficiency and environmental safety requirements. Among the existing technologies, hydrometallurgy is considered to be the most promising technology for e-waste recycling ...
Vera Serga, Aleksej Zarkov, Ervins Blumbergs, Andrei Shishkin, Janis Baronins, Edgars Elsts, Vladimir Pankratov   +6 more
doaj   +1 more source

ALTERNATING CURRENT ELECTROLYSIS.

Journal of the American Chemical Society, 1914
n ...
openaire   +1 more source