Results 101 to 110 of about 6,094,547 (359)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

A new additive ratio assessment (ARAS) method in multicriteria decision‐making / Naujas adityvinis kriterijų santykių įvertinimo metodas (aras) daugiakriteriniams uždaviniams spręsti

open access: yesTechnological and Economic Development of Economy, 2010
Multicriteria decision‐making (MCDM) methods are used in many areas of human activities. Each alternative in a multicriteria decision‐making problem can be described by a set of criteria. Criteria can be qualitative and quantitative.
Edmundas Kazimieras Zavadskas   +1 more
doaj   +1 more source

No Alternative to Proliferation [PDF]

open access: yes, 2019
15 pages; contribution to the volume "Why trust a theory?", edited by: R. Dardashti, R. Dawid, K.
openaire   +4 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Fuzzy Multi-criteria Selection of Alternatives by Quasi-best Case as the Basis for Choosing Robotic Machine-Assembling Technologies

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2020
The process of choosing the robotic machine - assembling technologies (RMAT) is implemented as the fuzzy multi - criteria selection of alternatives by the suggested previousely method of quasi - best case.
V.A. Kyrylovych   +6 more
doaj  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Alternative to Gravitons

open access: yes
Gravitons, postulated in 1934, have still not been found, leading to the search for an alternative. This paper proposes a new theory of gravity. It is strongly supported by an image of the nebula NGC 6302. It explains the flyby anomaly and the torsion of the Milky Way. It leads to the discovery of cosmic hydrogen purification.
openaire   +1 more source

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