Results 151 to 160 of about 3,304,692 (248)

Pleiotropy and the evolutionary stability of plastic phenotypes: a geometric framework. [PDF]

G3 (Bethesda)
Wang CQ, DuBose JG.
europepmc   +1 more source

Potential Alternative Hosts and Transmissibility of Potato virus Y [PDF]

, 2020
Mohamed N. Rizk, H. Ketta, Yasser M. Shabana   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon

, 2015
Alexander Gamboa, Valeria Araujo, Nelson Caro, Martín Gotteland, Lilian Abugoch, Cristián Tapia   +5 more
openalex   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Correction: Mid- and long-term evaluation of an alternative to the Liu' modified Bentall procedure for aortic root aneurysm. [PDF]

Front Cardiovasc Med
Wang Y, Wang W, Du T, Huang M, Li M, Liu K, Piao H, Zhu Z, Wang T, Liu K.   +9 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Rethinking DeepVariant: Efficient Neural Architectures for Intelligent Variant Calling. [PDF]

Int J Mol Sci
Gurianova A, Pestruilova A, Beliaeva A, Kasianov A, Mikhailova L, Guguchkin E, Karpulevich E.   +6 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Impact of carboplatin desensitization therapy on progression-free survival in gynecologic cancers. [PDF]

Gynecol Oncol Rep
Bastin N, Petrie H, Robinson M, Javid A, Lane R, Boucher T, Brown AJ, Prescott LS, Phillips E, Alvarez RD, Crispens M, Stone CA.   +11 more
europepmc   +1 more source