The alternative splicing landscape of hepatocellular carcinoma and its potential for HCC detection. [PDF]
Hepatol CommunHershberger CE +3 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Correction to "Ethanol-Extracted Cameroonian Propolis Counteracts Tamoxifen-Induced Endometrial Hyperplasia by Modulating Apoptosis and Proliferation-Regulating Proteins in Intact Wistar Rats". [PDF]
Evid Based Complement Alternat Medeuropepmc +1 more source
The reproducibility of structured functional assessments in a social security setting: a pre-specified explanatory analysis of the RELY-studies. [PDF]
Front PsychiatryKunz R +7 more
europepmc +1 more source
Alternative fuel for biomass boilers in Sri Lanka [PDF]
, 2019 Udara S.P.R Arachchige +1 more
openalex
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Correction to "The <i>In Vitro</i> Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research". [PDF]
Evid Based Complement Alternat Medeuropepmc +1 more source
Alternative splicing of KRAS exon 4 promotes tumor progression via enhanced KRAS4A oncogenic activity. [PDF]
Anim Cells Syst (Seoul)Cho N, Kwon E, Kim SE, Kim KK.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source